Expression of miR-148a in Human Meningioma Tumors

Document Type : Original Article(s)

Authors

1 Pediatrics Inherited Diseases Research Center AND Research Institute for Primordial Prevention of Non-communicable Diseases AND Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Assistant Professor, Pediatric Inherited Diseases Research Center, Research Institute for Primordial Prevention of Non-communicable Disease AND Department of Genetics and Molecular Biology, School of Medicine, Isfahan University Of Medical Sciences, Isfahan, Iran

Abstract

Background: Meningioma is one of the most prevalent brain tumors and is derived from meninges. Although, the tumor is usually benign and has limited numbers of genetic aberrations, but intracranial location often cause serious and lethal outcomes. Following role of phosphatase and tensin homolog (PTEN) protein, a tumor suppressor gene that is one of miR-148a targets in meningioma and as the microRNA has showed up regulation in brain tumor samples in microarray data, we assessed miR-148a expression pattern in meningioma.Methods: We evaluated miR-148a expression among 25 meningioma and 4 normal tissues using real-time polymerase chain reaction method.Findings: The expression level of miR-148a showed significant difference between meningioma and normal tissues (P < 0.05).Conclusion: As a result, since there is a significance difference in the miR-148a expression in meningioma tumors compared to normal tissues, the microRNA might be considered as a marker in meningiomas tumors, with further investigations.

Keywords

References

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Journal of Isfahan Medical School
Volume 33, Issue 325 - Serial Number 325
January and February 2015
Pages 252-257

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History

  • Receive Date: 04 April 2015
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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