Review of the Mechanisms of Caffeine Effect on Skin and Hair Health

Document Type : Review Article

Authors

1 Researcher, Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran

2 Researcher, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

3 Associate Professor, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan AND Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran

4 Associate Professor, Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran AND Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran

Abstract

Caffeine -a methylxanthine derived from purine- is found in the various plants (coffee, tea, cola) all over the world and is widely used in cosmetics due to its ability to penetrate in skin barriers. In this paper, the mechanism of broad effects of caffeine on skin and hair is discussed. Commercial use of caffeine in the formulation of cosmetics (e.g. sunscreen products) can effectively reduce Ultraviolet (UV) irradiation side effects and devastating UV induced free radicals. It inhibits phosphodiesterase activity, increases the concentration of cyclic adenosine monophosphate (cAMP) and augments apoptosis in damaged keratinocytes of skin. Caffeine inhibits cell cycle and induces apoptosis by inhibition of ataxia-telangiectasia mutated and Rad3-related (ATR), cycle ATR-chk function. On the other hand, Caffeine is topically used in shampoo as an adjuvant for hair loss treatment. Increasing the cAMP concentration caused by caffeine reduces the tension in smooth muscle near the hair follicle and leads to easier delivery of nutrients through blood vessels. It also prevents negative effects of testosterone on hair follicles in men. Most of currently used hair products contain caffeine. Detailed mechanisms of other effects of caffeine in this field are also discussed.

Keywords

References

  1. Boaventura G, Krause L, Queiroz N, Contreras CG. Cosmetics with caffeine: Real benefits versus marketing claims. Proceedings of the 22nd Conference of the International Federation of Societies of Cosmetic Chemists; 2013 Oct 30-Nov 1; Rio de Janeiro, Brazil. 2016.
  2. Herman A, Herman AP. Caffeine's mechanisms of action and its cosmetic use. Skin Pharmacol Physiol 2013; 26(1): 8-14.
  3. Vali A, Asilian A, Khalesi E, Khodami L, Shah Talebi MA. Evaluation of the efficacy of topical Caffeine in the treatment of Psoriasis Vulgaris: A randomized, double-blind clinical trial. Iran J Dermatol 2006; 8(34): 462-5. [In Persian].
  4. Boswell-Smith V, Spina D, Page CP. Phosphodiesterase inhibitors. Br J Pharmacol 2006; 147(Suppl 1): S252-S257.
  5. Otberg N, Teichmann A, Rasuljev U, Sinkgraven R, Sterry W, Lademann J. Follicular penetration of topically applied caffeine via a shampoo formulation. Skin Pharmacol Physiol 2007; 20(4): 195-8.
  6. Fischer TW, Hipler UC, Elsner P. Effect of caffeine and testosterone on the proliferation of human hair follicles in vitro. Int J Dermatol 2007; 46(1): 27-35.
  7. Trommer H, Neubert RH. Overcoming the stratum corneum: the modulation of skin penetration. A review. Skin Pharmacol Physiol 2006; 19(2): 106-21.
  8. Touitou E, Levi-Schaffer F, Dayan N, Alhaique F, Riccieri F. Modulation of caffeine skin delivery by carrier design: liposomes versus permeation enhancers. International Journal of Pharmaceutics 1994; 103(2): 131-6.
  9. Mustapha RB, Lafforgue C, Fenina N. Effect of concentration on skin permeation of caffeine from gel formulations. Journal of Pharmacy and Bioresources 2010; 7(2): 43-54.
  10. Shakeel F, Ramadan W. Transdermal delivery of anticancer drug caffeine from water-in-oil nanoemulsions. Colloids Surf B Biointerfaces 2010; 75(1): 356-62.
  11. Lopes LB. Overcoming the cutaneous barrier with microemulsions. Pharmaceutics 2014; 6(1): 52-77.
  12. Bourgeois S, Bolzinger MA, Pelletier J, Valour JP, Briancon S. Caffeine microspheres - an attractive carrier for optimum skin penetration. Int J Cosmet Sci 2010; 32(4): 318.
  13. Schneider M. Investigation of nanoparticulate formulation intended for caffeine delivery to hair follicles [Dissertation]. Saarbrücken, Germany: Saarland University; 2013.
  14. Amnuaikit T, Maneenuan D, Boonme P. Evaluation of caffeine gels on physicochemical characteristics and in vivo efficacy in reducing puffy eyes. J App Pharm Sci 2011; 1(2): 56-9.
  15. Lupi O, Semenovitch IJ, Treu C, Bottino D, Bouskela E. Evaluation of the effects of caffeine in the microcirculation and edema on thighs and buttocks using the orthogonal polarization spectral imaging and clinical parameters. J Cosmet Dermatol 2007; 6(2): 102-7.
  16. Leon-Carmona JR, Galano A. Is caffeine a good scavenger of oxygenated free radicals? J Phys Chem B 2011; 115(15): 4538-46.
  17. Kerzendorfer C, O'Driscoll M. UVB and caffeine: inhibiting the DNA damage response to protect against the adverse effects of UVB. J Invest Dermatol 2009; 129(7): 1611-3.
  18. Abel EL, Hendrix SO, McNeeley SG, Johnson KC, Rosenberg CA, Mossavar-Rahmani Y, et al. Daily coffee consumption and prevalence of nonmelanoma skin cancer in Caucasian women. Eur J Cancer Prev 2007; 16(5): 446-52.
  19. Lu YP, Lou YR, Xie JG, Peng QY, Liao J, Yang CS, et al. Topical applications of caffeine or (-)-epigallocatechin gallate (EGCG) inhibit carcinogenesis and selectively increase apoptosis in UVB-induced skin tumors in mice. Proc Natl Acad Sci USA 2002; 99(19): 12455-60.
  20. Conney AH, Kramata P, Lou YR, Lu YP. Effect of caffeine on UVB-induced carcinogenesis, apoptosis, and the elimination of UVB-induced patches of p53 mutant epidermal cells in SKH-1 mice. Photochem Photobiol 2008; 84(2): 330-8.
  21. Heffernan TP, Kawasumi M, Blasina A, Anderes K, Conney AH, Nghiem P. ATR-Chk1 pathway inhibition promotes apoptosis after UV treatment in primary human keratinocytes: potential basis for the UV protective effects of caffeine. J Invest Dermatol 2009; 129(7): 1805-15.
  22. Otberg N, Patzelt A, Rasulev U, Hagemeister T, Linscheid M, Sinkgraven R, et al. The role of hair follicles in the percutaneous absorption of caffeine. Br J Clin Pharmacol 2008; 65(4): 488-92.
  23. Golpour M, Rabbani H, Farzin D, Azizi F. Comparing the effectiveness of local solution of minoxidil and caffeine 2.5% with local solution of minoxidil 2.5% in treatment of androgenetic alopecia. J Mazandaran Univ Med Sci 2013; 23(106): 30-6. [In Persian].
  24. Teichmann A, Richter H, Knorr F, Antoniou C, Sterry W, Lademann J. Investigation of the penetration and storage of a shampoo formulation containing caffeine into the hair follicles by in vivo laser scanning microscopy. Laser Phys Lett 2007; 4(6): 464-8.
  25. Treffel P, Muret P, Muret-D'Aniello P, Coumes-Marquet S, Agache P. Effect of occlusion on in vitro percutaneous absorption of two compounds with different physicochemical properties. Skin Pharmacol 1992; 5(2): 108-13.
  26. Trauer S, Patzelt A, Otberg N, Knorr F, Rozycki C, Balizs G, et al. Permeation of topically applied caffeine through human skin--a comparison of in vivo and in vitro data. Br J Clin Pharmacol 2009; 68(2): 181-6.
  27. Davis MG, Thomas JH, van de Velde S, Boissy Y, Dawson TL, Iveson R, et al. A novel cosmetic approach to treat thinning hair. Br J Dermatol 2011; 165(Suppl 3): 24-30.
Journal of Isfahan Medical School
Volume 34, Issue 376 - Serial Number 376
January and February 2016
Pages 299-305

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History

  • Receive Date: 27 September 2015
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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