The Effect of Ultrasound Waves on Melanoma Cells in Presence of Gold Nanoparticles

Document Type : Original Article (s)

Authors

1 Associated Professor, Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 PhD Student, Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 PhD Student, Department of Nano Materials, School of Materials Engineering, Tarbiat Modares University, Tehran, Iran

Abstract

-Background: Biological effects of ultrasound waves and their applications in the presence of nanoparticles are a rapidly growing research area. In recent years, ultrasonic therapy of cancer cells has been developed successfully. In this study, effects of ultrasound waves in the presence of gold nanoparticles on the melanoma cells were evaluated.Methods: The Melanoma cells were cultured and divided into 4 groups of control, gold nanoparticle, ultrasound alone and ultrasound waves at the presence of gold nanoparticle. Ultrasound irradiation at intensity of 2 W/cm2 was performed on the cells for 3 minutes.Findings: There was a significant difference in the percent of cell viability between the ultrasound + gold nanoparticles and the other groups. In addition, there was a significant difference between the ultrasound and the control groups, too.Conclusion: Results of this study reveal that ultrasound in the presence of gold nanoparticles can be efficiently used for treatment of melanoma cells; as gold nanoparticles act as cavitation nuclei.

Keywords

References

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Journal of Isfahan Medical School
Volume 34, Issue 412 - Serial Number 412
November and December 2017
Pages 1550-1555

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History

  • Receive Date: 08 October 2016
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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