عوامل ژنتیکی ناباروری در مردان

نوع مقاله : مقاله مروری

نویسندگان

1 دانشجوی کارشناسی ارشد، گروه ژنتیک و بیولوژی مولکولی، دانشکده‌ی پزشکی و کمیته‌ی تحقیقات دانشجویی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

2 استادیار، مرکز تحقیقات بیماری‌های ارثی کودکان، گروه ژنتیک و بیولوژی مولکولی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

چکیده

ناباروری یکی از شایع‌ترین مشکلات بهداشتی جهان است. این مشکل حدود 15 درصد زوج‌ها را درگیر می‌کند. در حدود نیمی از این موارد یک عامل مردانه دخیل است. سبب‌شناسی ناباروری در مردان به صورت چند عاملی است و بسیاری از عوامل ژنتیکی و محیطی در بروز آن دخیل هستند. عوامل ژنتیکی شامل ناهنجاری‌های کروموزومی و جهش‌های تک ژنی مسؤول حدود 10 تا 15 درصد عوامل در مردان نابارور است. در این مقاله ما به جنبه‌ها‌ی ژنتیکی (ناهنجاری کروموزومی، تک ژنی و پلی‌مورفیسم ژن‌های دخیل)، نقش جهش‌های میتوکندریایی، ارتباط miRNA با ناباروری و گزارش ژن‌های جدید در ناباروری در سال‌های اخیر پرداختیم. 

کلیدواژه‌ها

عنوان مقاله [English]

Genetics Aspects of Male Infertility

نویسندگان [English]

  • Arezoo Karamzade 1
  • Hadi Mirzapour 1
  • Majid Kheirollahi 2
1 MSc Student, Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Assistant Professor, Pediatric Inherited Diseases Research Center AND Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده [English]

Infertility is one of the most common reproductive disorders occurring in approximately 15% of the couples. Male factor accounts for about half of these cases. The causes of reproductive defects in infertile men are multifactorial and many environmental and genetic factors affect male infertility. Genetics factors cause an account for 10-15% of male infertility, including chromosomal aberrations and single gene mutations. The current review will focus on genetics aspect of male infertility, including chromosomal disorder, single gene mutation and polymorphism, role of mitochondrial DNA and microRNA. We also take a look at last reported new genes causes of infertility. 

کلیدواژه‌ها [English]

  • Infertility
  • Spermatogenesis
  • Chromosome abnormality
  • Epigenetics

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مجله دانشکده پزشکی اصفهان
دوره 31، شماره 246 - شماره پیاپی 246
مرداد و شهریور 1392
صفحه 1149-1162

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سابقه مقاله

  • تاریخ دریافت: 21 فروردین 1392
  • تاریخ بازنگری: 11 آبان 1403
  • تاریخ پذیرش: 17 فروردین 1401

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