Genetics Aspects of Male Infertility

Document Type : Review Article

Authors

1 MSc Student, Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Assistant Professor, Pediatric Inherited Diseases Research Center AND Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Infertility is one of the most common reproductive disorders occurring in approximately 15% of the couples. Male factor accounts for about half of these cases. The causes of reproductive defects in infertile men are multifactorial and many environmental and genetic factors affect male infertility. Genetics factors cause an account for 10-15% of male infertility, including chromosomal aberrations and single gene mutations. The current review will focus on genetics aspect of male infertility, including chromosomal disorder, single gene mutation and polymorphism, role of mitochondrial DNA and microRNA. We also take a look at last reported new genes causes of infertility. 

Keywords

References

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Journal of Isfahan Medical School
Volume 31, Issue 246 - Serial Number 246
May and June 2013
Pages 1149-1162

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History

  • Receive Date: 10 April 2013
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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