عملکرد Uncoupling proteinها در بافت‌های مختلف

نوع مقاله : مقاله مروری

نویسندگان

1 دانشیار، گروه زیست‌شناسی، دانشکده‌ی علوم، دانشگاه فردوسی مشهد، مشهد، ایران

2 دانشجوی دکتری، گروه زیست‌شناسی، دانشکده‌ی علوم، دانشگاه فردوسی مشهد، مشهد، ایران

چکیده

مقدمه: یک سلول برای انجام فعالیت‌های خود نیازمند انرژی است. میتوکندری‌ها ماشین تولید انرژی در سلول هستند. UCPs (Uncoupling protein)، پروتئین‌هایی هستند که در غشای داخلی میتوکندری وجود دارند و باعث نشت پروتون از فضای بین دو غشا به ماتریکس میتوکندری می‌شوند. پر واضح است که تغییر در شیب پروتونی موجود در عرض غشای داخلی میتوکندری، تولید (Adenosine triphosphate) ATP را تحت تأثیر قرار می‌دهد. در این مقاله نقش این پروتئین‌ها در بافت‌های مختلف منجمله بافت‌های محیطی و عصبی مرکزی مرور شده است.روش‌ها: مطالعه‌ی کنونی با استفاده از پایگاه‌های اطلاعاتی PubMed، Elsevier، NCBI و EBSCO به بررسی 63 مقاله منتشر‌شده پرداخت تا عملکرد UCPها را در بافت‌های مختلف تشریح کند.یافته‌ها: مطالعات مختلف نشان داده‌اند که UCPها انواع مختلفی دارند و هر نوع از آن‌ها بر اساس بافتی که در آن قرار گرفته‌اند باعث تغییراتی در فعالیت سلول می‌شوند.نتیجه‌گیری: مطالعات در زمینه‌ی نقش این پروتئین‌ها در سیستم عصبی بیشتر به محیط In vitro محدود می‌شود و نیاز به بررسی‌های بیشتر در رابطه با نقش این پروتئین‌ها در شرایط فیزیولوژیک و پاتولوژیک در شرایط In vivo احساس می‌شود. بررسی عملکردهای فیزیولوژیک این پروتئین‌ها می‌تواند راهکارهای جدیدی را برای درمان بیماری‌های نورودژنراتیو بگشاید.

کلیدواژه‌ها

عنوان مقاله [English]

The Function of Uncoupling Proteins in Various Tissues

نویسندگان [English]

  • Masoud Fereidoni 1
  • Zohreh Abbasi 2
1 Associate Professor, Department of Biology, School of Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
2 PhD Student, Department of Biology, School of Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
چکیده [English]

Background: A cell requires energy to do its work. Mitochondria are the energy-producing machines of the cell. Uncoupling proteins (UCPs) located in the inner mitochondrial membrane cause a proton leak from the intermembrane space to the matrix. Clearly, the changes in the proton gradient across the inner membrane affect ATP production. In this paper, the role of these proteins in different tissues as well as peripheral and central nervous tissues has been reviewed.Methods: This study has reviewed 63 publications explaining the various functions of UCPs in different tissues using PubMed, Elsevier, NCBI and EBSCO databases.Findings: Several studies have shown that UCPs, based on the type of tissue, change the cell activity.Conclusion: Studies related to UCPs roles in the nervous system are mostly restricted to the in-vitro situations; thus more investigation seems to be needed to reveal the UCPs actions in the in-vivo conditions of physiologic and pathologic studies. These studies potentially can open some new therapeutic strategies and hopes to cure neurodegenerative diseases.

کلیدواژه‌ها [English]

  • Uncoupling proteins
  • Mitochondria
  • ATP
  • Cell activity

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مجله دانشکده پزشکی اصفهان
دوره 31، شماره 241 - شماره پیاپی 241
مرداد و شهریور 1392
صفحه 903-922

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  • تاریخ دریافت: 07 اسفند 1391
  • تاریخ بازنگری: 12 آبان 1403
  • تاریخ پذیرش: 17 فروردین 1401

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