In-Vitro Effect of Menthe Piperita and Salvia Officinalis Extracts on Trichomonas Vaginalis

Document Type : Original Article (s)

Authors

1 Student of Medicine, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran

2 Department of Mycology and Parasitology, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran

3 MSc Student, Department of Mycology and Parasitology, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran

4 Professor, Department of Pharmacology, School of Medicine AND Herbal Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran

5 Professor, Infectious Diseases and Tropical Medicine Research Center AND Department of Mycology and Parasitology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Trichomonas vaginalis is a flagellate parasite causing vaginosis, a common sexual transmitted disease. Metronidazole is the drug of choice for this disease but due to its side effects, it is necessary to search for an alternative drug. In this study, the effect of Menthe piperita and Salvia officinalis on Trichomonas vaginalis was investigated.Methods: Hydro-alcoholic extracts of the two herbs were prepared. The extracts were dried using vacuum rotary evaporator. Different concentrations of the extracts in comparison with methronidazole were added in test tubes containing culture medium and the parasite. All test tubes were kept in 37ºC for 24 hours. The tubes were then expected for the parasite growth.Findings: In concentrations of 2, 2.5, 4, 5, 8, and 10 mg/ml of Salvia officinalis and in concentrations of 4, 5, 8, and 10 mg/ml of Menthe piperita the parasite did not grow. The effect of the extracts on Trichomonas vaginalis was similar to the effect of metronidazole on the parasite.Conclusion: Salvia officinalis and Menthe piperita had efficient effect against Trichomonas vaginalis growth in culture medium and s,o these two herbs can be considered as alternatives drugs. However, more investigation is recommended.

Keywords

References

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Journal of Isfahan Medical School
Volume 31, Issue 240 - Serial Number 240
May and June 2013
Pages 811-818

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History

  • Receive Date: 20 November 2012
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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