Effect of Maternal Diabetes on Developing of Central Nervous System

Document Type : Review Article

Authors

1 PhD Student, Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Professor, Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 Assistant Professor, Department of Anatomical Sciences, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran

Abstract

Diabetes in pregnancy is the most common and the most important metabolic condition, since it can result in several fetal malformations. Maternal hyperglycemia may have teratogenic effect for developing of fetal central nervous system (CNS). Several lines of evidence indicate that the children born to diabetic mothers, exhibit disturbances in behavioral and intellectual functioning. The hippocampus subserves important behavioral and physiological functions such as memory consolidation, and is a brain structure particularly vulnerable to changes in glucose concentration. Hippocampal neurogenesis might underlie particular aspects of neuronal plasticity and might play an important role for the memory and cognitive functions. We reviewed the current understanding of the effect of diabetes on developing of central nervous system during the pregnancy.

Keywords

References

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Journal of Isfahan Medical School
Volume 33, Issue 335 - Serial Number 335
March and April 2015
Pages 755-769

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History

  • Receive Date: 09 August 2014
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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