تأثیر تمرین هوازی بر غلظت پلاسمایی آنزیم مبدل آنژیوتنسین (ACE) زنان یائسه

نوع مقاله : مقاله های پژوهشی

نویسندگان

1 کارشناس ارشد، گروه فیزیولوژی ورزش، دانشکده‌ی تربیت بدنی و علوم ورزشی، دانشگاه مازندران، بابلسر، ایران

2 دانشیار، گروه فیزیولوژی ورزش، دانشکده‌ی تربیت بدنی و علوم ورزشی، دانشگاه مازندران، بابلسر، ایران

3 استادیار، گروه فیزیولوژی ورزش، دانشکده‌ی تربیت بدنی و علوم ورزشی، دانشگاه مازندران، بابلسر، ایران

چکیده

مقدمه: آنزیم مبدل آنژیوتنسین (ACE یا Angiotensin-converting enzyme) مترشحه از اندوتلیال عروق، یکی از عوامل اصلی تنظیم فشار خون می‌باشد. هدف این پژوهش بررسی اثر یک دوره تمرین هوازی بر غلظت پلاسمایی ACE در زنان یائسه بود.روش‌ها: آزمودنی‌های این پژوهش شامل 14 زن یائسه (65-40 ساله) بودند. سطوح پلاسمایی ACE، شاخص‌های پیکرسنجی، اکسیژن مصرفی بیشینه (max2VO) و فشار خون سیستولیک و دیاستولیک پیش و پس از یک دوره برنامه‌ی تمرینی ارزیابی شد. برنامه‌ی تمرین هوازی در هفته‌ی اول با شدت 45-40 درصد حداکثر ضربان قلب ذخیره بود و به تدریج در هفته‌ی هشتم به 80-70 درصد حداکثر ضربان قلب ذخیره رسید.یافته‌ها: پس از 8 هفته تمرین هوازی، سطوح پلاسمایی ACE به طور معنی‌داری در آزمودنی‌ها افزایش یافت (020/0 = P). کاهش معنی‌دار دور کمر نیز در زنان یائسه مشاهده شد (001/0 > P). اکسیژن مصرفی بیشینه در آزمودنی‌ها افزایش معنی‌دار داشت (001/0 = P). تغییرات سطوح پلاسمایی ACE ارتباط منفی و معنی‌داری با تغییرات دور کمر (020/0 = P و 601/0- = r)، تغییرات وزن (010/0 = P و 630/0- = r) و تغییرات BMI (Body mass index) (010/0 = P و 637/0- = r) داشت.نتیجه‌گیری: تمرین هوازی موجب افزایش سطوح پلاسمایی ACE در زنان یائسه بدون تغییر معنی‌داری در ترکیب بدنی و فشار خون آن‌ها می‌شود. مطالعات بیشتر با تعداد آزمودنی‌های زیادتر به منظور تأیید این نتیجه ضرورت دارد. 

کلیدواژه‌ها

عنوان مقاله [English]

Effect of Aerobic Training on Concentration of Plasma Angiotensin-Converting Enzyme (ACE) in Postmenopausal Women

نویسندگان [English]

  • Maryam Mirhaj 1
  • Elahe Talebi-Garakani 2
  • Rozita Fathi 2
  • Alireza Safarzadeh 3
1 Department of Exercise Physiology, School of Physical Education and Sport Science, University of Mazandaran, Babolsar, Iran
2 Associate Professor, Department of Exercise Physiology, School of Physical Education and Sport Science, University of Mazandaran, Babolsar, Iran
3 Assistant Professor, Department of Exercise Physiology, School of Physical Education and Sport Science, University of Mazandaran, Babolsar, Iran
چکیده [English]

Background: Angiotensin converting enzyme (ACE) is secreted from vascular endothelium. This enzyme is one of the main determinants of blood pressure regulation. This study aimed to investigate the effect of aerobic training on plasma concentration of angiotensin-converting enzyme in postmenopausal women.Methods: 14 postmenopausal women (40-65 years old) were enrolled. Plasma levels of angiotensin-converting enzyme, anthropometric indices, maximal oxygen uptake (VO2max), and systolic and diastolic blood pressure were measured before and after a training program. The exercise intensity started by 40-45% of maximum heart rate reserve for the first week and gradually received to 70-80% of maximum heart rate reserve in eight weeks.Findings: The plasma levels of angiotensin-converting enzyme after 8 weeks of aerobic exercise significantly increased (P = 0.020). In addition, a significant decrease in waist circumference was observed (P < 0.001). Maximal oxygen uptake increased significantly, too (P < 0.001). There was significant negative correlation between the changes in angiotensin-converting enzyme and the changes in waist circumference (P = 0.020, r = -0.601), weight (P = 0.020, r = -0.63) and body mass index (BMI) (P = 0.010, r = -0.637).Conclusion: This study indicated that aerobic training could increase plasma levels of angiotensin-converting enzyme in postmenopausal women, without significant changes in body composition and blood pressure. Further studies with more numbers of subjects are needed to confirm these results.

کلیدواژه‌ها [English]

  • Angiotensin-converting enzyme
  • Aerobic training
  • Blood Pressure
  • Fat percentage
  • Body composition

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مجله دانشکده پزشکی اصفهان
دوره 32، شماره 310 - شماره پیاپی 310
آذر و دی 1393
صفحه 1965-1975

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  • تاریخ دریافت: 16 مهر 1392
  • تاریخ بازنگری: 11 آبان 1403
  • تاریخ پذیرش: 17 فروردین 1401

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