Risk Factors of Metastasis in Women with Breast Cancer in Isfahan, Iran

Document Type : Original Article (s)

Authors

1 Associate Professor, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Student of Medicine, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 Community Medicine Specialist, Isfahan University of Medical Sciences, Isfahan, Iran

4 Student of Medicine, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran

Abstract

Background: Breast cancer is one of the most common malignancies in women and its metastasis plays an important role in mortality, treatment failures and complications. The objective of this study was to evaluate the risk factors of metastatic breast cancer.Methods: In a retrospective cohort study, breast cancer patients in Isfahan, Iran were followed up for ten years. The existence of metastasis was considered as the dependent variable while independent variables included age at diagnosis, hormone receptor status, family history, number of lymph nodes dissected in surgery and involved ones, number of pregnancies, age at first pregnancy and menarche, menstrual status, histopathology and tumor size. All data was collected from patients' profiles and analyzed using logistic regression in SPSS16.Findings: A total of 685 patients with breast cancer were studied during 1999-2009. While 91.4% of cases had no metastasis, distant metastasis was found in 8.6% of subjects. Sites of metastasis according to prevalence were lung (4.7%), bone (2.6%), other organs (1.1%), and liver (0.3%). Number of involved lymph nodes (P = 0.043) and number of pregnancies (P = 0.022) had significant relationships with metastasis.Conclusion: We concluded that less pregnancies and more involved lymph nodes indicate a high probability of metastasis occurrence. Therefore, survival improvement might be possible with early diagnosis of breast cancer, using prophylactic treatments, and identifying metastatic cases by diagnostic tests.

Keywords

References

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Journal of Isfahan Medical School
Volume 29, Issue 171 - Serial Number 171
November and December 2012
Pages 2785-2796

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History

  • Receive Date: 31 January 2012
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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