8-Year Survival Analysis of Kidney Transplantation and Determining the Factors Affecting it in Kidney-Transplanted Patients in Noor Hospital in Isfahan, Iran

Document Type : Original Article (s)

Authors

1 Assistant Professor, Department of Biostatistics and Epidemiology, School of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

2 Professor, Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

3 Assistant Professor, Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

4 Assistant Professor, Department of Internal Medicine, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

5 MSc Student, Department of Biostatistics and Epidemiology, School of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Abstract

Background: Kidney transplantation is the preferred treatment for most patients with end-stage renal disease (ESRD) and therefore, kidney transplantation survival analysis is important. The aim of this study was to determine the cumulative survival rate of renal transplantation and the factors affecting it.Methods: This was a historic cohort study including information of 381 patients with end-stage renal disease who underwent kidney transplantation surgery from December 2007 to March 2016 in Noor hospital, Isfahan, Iran. The Kaplan-Meier method, Log Rank test and Cox regression model were used for statistical analysis. Data analysis was carried out with R software, Version 3.1.0, at the significance level of P < 0.05.Findings: According to Kaplan-Mayer method, 1-, 3-, 5- and 8-year survival rates of transplanted kidney were estimated as 98.7, 93.3, 86.9, and 83.9 percent, respectively. The results of Cox regression model indicated that the time duration of dialysis before transplantation (P < 0.05), and the level of creatinine at the time of discharge from hospital (P < 0.05) had significant relationship with survival of transplanted kidney.Conclusion: The survival rate of the transplanted kidney calculated for this center was suitable in comparison with other transplant centers. The level of creatinine at the time of discharge from hospital and the time duration of dialysis prior to transplantation were the factors influencing survival of the graft.

Keywords

References

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Journal of Isfahan Medical School
Volume 35, Issue 442 - Serial Number 442
July and August 2017
Pages 1022-1029

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History

  • Receive Date: 29 July 2017
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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