ارتباط شاخص‌های کاردیومتابولیک، کبدی و دریافت غذایی بین گروه‌های چاقی متابولیکی: یک مطالعه‌ی مقطعی از کوهورت هویزه

نوع مقاله : Original Article(s)

نویسندگان

1 دانشیار، گروه بیماری‌های داخلی، مرکز تحقیقات دیابت، پژوهشکده‌ی سلامت، دانشگاه علوم پزشکی جندی شاپور اهواز، اهواز، ایران

2 دستیار فوق تخصص غدد درون‌ریز و متابولیسم، گروه بیماری‌های داخلی، مرکز تحقیقات دیابت، پژوهشکده‌ی سلامت، دانشگاه علوم پزشکی جندی شاپور اهواز، اهواز، ایران

3 استادیار، گروه علوم تغذیه، دانشکده‌ی علوم پزشکی شوشتر، شوشتر، ایران

4 استادیار، گروه بیماری‌های داخلی، مرکز تحقیقات دیابت، پژوهشکده‌ی سلامت، دانشگاه علوم پزشکی جندی شاپور اهواز، اهواز، ایران

چکیده

مقاله پژوهشی




مقدمه: نقش وضعیت متابولیکی در بیماری‌های قلبی- عروقی، استئاتوز کبدی و تغذیه در بین گروه‌های چاقی متابولیکی مبهم است. این مطالعه با هدف مقایسه‌ی شاخص‌های کاردیومتابولیکی، کبدی و دریافت غذایی در بین گروه‌های چاقی متابولیکی انجام شد.
روش‌ها: 7464 شرکت‌کننده از شهر هویزه در این مطالعه‌ی مقطعی، به چهار گروه وزن طبیعی با وضعیت متابولیکی سالم (Metabolically healthy normal weight) MHNW و ناسالم (Metabolically unhealthy normal weight) MUNW، وزن غیرطبیعی (اضافه وزن-چاق) با وضعیت متابولیکی سالم
(Metabolically healthy overweight/obese) MHOO و ناسالم (Metabolically unhealthy overweight/obese) MUOO تقسیم شدند. شاخص‌های کاردیومتابولیکی، کبدی و دریافت غذایی در بین گروه‌ها مقایسه شدند.
یافته‌ها: گروه پرخطر MUOO، بیشترین فراوانی (57/36 درصد) را در بین گروه‌های چاقی متابولیکی داشت. نسبت دور کمر به لگن، شاخص چربی احشایی و شاخص دور کمر تعدیل شده برای وزن و اکثر شاخص‌های کاردیومتابولیکی در گروه‌های ناسالم متابولیکی به طور معنی‌دار مقادیر بیشتری داشتند. شاخص‌های کبدی در گروه‌های دارای اضافه وزن-چاق به طور معنی‌دار بزرگتر بودند. گروه‌های MUNW و MUOO بیشترین ارتباط مثبت را به ترتیب با شاخص ترکیب لیپوپروتئین و شاخص استئاتوز کبدی داشتند (0/001 > P). بیشترین دریافت چربی کل و اسید چرب تک غیر اشباع در گروه‌های MHNW و MHOO و بیشترین دریافت چربی اشباع در گروه MHNW بود.
نتیجه‌گیری: گروه MUNW خطر بیشتری برای بیماری‌های قلبی- عروقی در مقایسه با گروه MHOO داشتند، پس ارتباط سلامتی متابولیکی با بیماری‌های قلبی- عروقی مهم‌تر از ارتباط چاقی با آن است. خطر استئاتوز کبدی و کبد چرب غیر الکلی در وزن غیرطبیعی بیشتر بود.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Association between Cardio-Metabolic and Hepatic Indices and, Dietary Intake between Metabolically Obesity Groups: A Cross-Sectional Study of the Hoveyzeh Cohort

نویسندگان [English]

  • Mehrnoosh Zakerkish 1
  • Azamsadat Hoseinian 2
  • Meysam Alipour 3
  • Seyed Peyman Payami 4
1 Associate Professor, Department of Internal Medicine, Diabetes Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2 Subspecialty Resident of Endocrinology & Metabolism, Department of Internal Medicine, Diabetes Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3 Assistant Professor, Department of Nutrition, Shoushtar Faculty of Medical Sciences, Shoushtar, Iran
4 Assistant Professor, Department of Internal Medicine, Diabetes Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
چکیده [English]

Background: The role of metabolic status on cardiovascular disease, hepatic steatosis and, nutrition between metabolically obesity groups is unclear. This study aimed to compare the cardio-metabolic and hepatic indices and, among dietary intake among metabolically obesity groups.
Methods: In this cross-sectional study, 7464 participants in the city of Hoveyzeh classified into four groups: MHNW: Metabolically Healthy Normal Weight, MUNW: Metabolically Unhealthy Normal Weight, MHOO: Metabolically Healthy Overweight/obese, MUOO: Metabolically Unhealthy Overweight/obese. Cardio-metabolic and hepatic indices and, dietary intake were compared among groups.
Findings: The MUOO high risk group had the highest frequency (57.36%) among the metabolic obesity groups. The values of Waist to Hip Ratio (WHR), Visceral Adiposity Index (VAI) and Weight-Adjusted Waist Index (WWI) and, most of the cardio-metabolic indices in metabolically unhealthy groups were significantly higher but, hepatic indices in overweight-obese groups were significantly greater. The MUNW and MUOO groups had the most positive relation with Lipoprotein Combine Index (LCI) and Hepatic Steatosis Index (HSI), respectively. The highest intake of total fat and mono-unsaturated fatty acid was in the MHNW and MHOO groups, and the highest intake of saturated fat was in MHNW group.
Conclusion: MUNW group had a higher risk for cardiovascular diseases than MHOO group. The association between metabolic health and cardiovascular diseases is more important than obesity with that. Hepatic steatosis and non-alcoholic fatty liver risk were higher in the individuals with abnormal weights.

کلیدواژه‌ها [English]

  • Cardiovascular
  • Hepatic steatosis
  • obesity
  • abdominal obesity

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مجله دانشکده پزشکی اصفهان
دوره 41، شماره 723
هفته 3 مرداد
مرداد و شهریور 1402
صفحه 464-478

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  • تاریخ دریافت: 21 اسفند 1401
  • تاریخ پذیرش: 18 مرداد 1402

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