Echocardiographic Changes after Treatment with Anthracyclines in Children

Document Type : Original Article (s)

Authors

1 Associate Professor, Department of Pediatrics, Cardiac Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

2 Resident, Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz, Iran

3 Assistant Professor, Department of Pediatrics, Hematology Research Center, Shiraz Universi

Abstract

Background: In this study, we evaluated systolic and diastolic changes over time after treatment with anthracyclines in children.Methods: In this study, 25 patients aged 1-17.5 years were assessed. Echocardiography was performed just after starting chemotherapy, 6 months and one year after stating of anthracyclines. Echocardiography results of 25 healthy aged matched children were recorded as the control group.Findings: The average anthracycline dose was 371 mg/m2 (range: 100-690 mg/m2) before the third echocardiography. M-mode echocardiography did not show statistically significant differences. However, Doppler and pulse tissue Doppler showed statistically significant changes between the first echocardiography, and those performed six and one year later (P < 0.05).In tissue Doppler echocardiogram statistically significant changes were observed in systolic wave of septum, atrial wave of anterior wall, early and late diastolic wave of lateral tricuspid and mitral valve. There was a statistically significant correlation between wave changes and the anthracycline dose received. Conclusion: According to our study, tissue Doppler echocardiography can detect early cardiac abnormalities which cannot be detected by two-dimensional echocardiography. Such changes are dose-dependent.

Keywords

References

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Journal of Isfahan Medical School
Volume 29, Issue 170 - Serial Number 170
November and December 2012
Pages 2705-2714

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History

  • Receive Date: 07 May 2011
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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