بررسی تأثیر باکتریوفاژها علیه عفونت‌های ناشی از باکتری‌های گرم منفی در شرایط In Vivo: مطالعه‌ی مروری سیستماتیک

نوع مقاله : مقاله مروری

نویسندگان

1 دانشجوی دکتری پژوهشی، مرکز تحقیقات عفونی اطفال، دانشگاه علوم پزشکی مازندران، ساری، ایران

2 مرکز تحقیقات عفونی اطفال، دانشگاه علوم پزشکی مازندران، ساری، ایران

3 استاد، مرکز تحقیقات عفونی اطفال، دانشگاه علوم پزشکی مازندران، ساری، ایران

چکیده

مقدمه: عفونت‌های ناشی از باکتری‌های گرم منفی مقاوم به چندین آنتی‌بیوتیک (Multi drug resistant یا MDR) در حال افزایش می‌باشد. باکتریوفاژها به عنوان گزینه‌ی درمانی جایگزین، جهت درمان عفونت‌های ناشی از باکتری‌های مقاوم به آنتی‌بیوتیک‌ها پیشنهاد شده‌اند. تاکنون در منابع انگلیسی و فارسی از باکتریوفاژها به منظور درمان عفونت‌های ناشی از باکتری‌های گرم منفی در مطالعات حیوانی به خوبی بحث نشده است. پژوهش حاضر با هدف بررسی تأثیر باکتریوفاژها علیه عفونت‌های ناشی از باکتری‌های گرم منفی در شرایط In vivo انجام شد.روش‌ها: این تحقیق از نوع مروری سیستماتیک بود که در آن مقالات منتشر شده طی سال‌های 1983 تا 2018 در پایگاه‌های معتبر بین‌المللی Scopus، PubMed، Google Scholar و Web of Science جستجو گردید. مطالعاتی که دارای معیارهای ورود بودند، مورد بررسی قرار گرفت و داده‌ها با روش مروری برآورد گردید.یافته‌ها: 1310 مقاله در پایگاه‌های مورد نظر نمایش داده شد. پس از بررسی عناوین، 380 مقاله برگزیده شد. پس از مرور چکیده و حذف مطالعات تجربی و In vitro و انتخاب پژوهش‌های انگلیسی زبان که در شرایط In vivo انجام شده بود، 31 مقاله‌ی منتشر شده در بازه‌ی زمانی مورد نظر انتخاب گردید.نتیجه‌گیری: استفاده‌ی خوراکی، تزریقی و موضعی از باکتریوفاژها علیه عفونت‌های ناشی از باکتری‌های گرم منفی در مدل حیوانی مؤثر می‌باشد.

کلیدواژه‌ها

عنوان مقاله [English]

The Effect of Bacteriophages against Gram-Negative Bacteria Infections in Vivo: A Systematic Review

نویسندگان [English]

  • Golnar Rahimzadeh 1
  • Fereshteh Farshidi 2
  • Mohammad Sadegh Rezai 3
  • Shaghayegh Rezai 2
1 PhD Student, Pediatric Infectious Diseases Research Center, Mazandaran University of Medical Sciences, Sari, Iran
2 Pediatric Infectious Diseases Research Center, Mazandaran University of Medical Sciences, Sari, Iran
3 Professor, Pediatric Infectious Diseases Research Center, Mazandaran University of Medical Sciences, Sari, Iran
چکیده [English]

Background: Infections caused by multidrug-resistant (MDR) Gram-negative bacteria are rising. Bacteriophages are suggested as an alternative treatment option for the treatment of antibiotic-resistant bacteria. Bacteriophages in treatment of Gram-negative bacterial infections is not well investigated in vivo. The aim of this study was to review systematically the studies on bacteriophages against infection caused by Gram-negative bacteria in vivo.Methods: This systematic review was done using electronic databases, including Scopus, PubMed, Google Scholar, and Web of science; the articles published from 1983 to 2018 were investigated. Studies meeting the inclusion criteria were selected, and the data were estimated using a review method.Findings: 1310 articles were indexed from which 380 were selected based on their abstracts. Then, some were excluded including clinical trials and in-vitro studies. Finally, experimental studies (n = 31), that met the inclusion criteria and were published in English, were selected.Conclusion: This review showed that bacteriophages are an effective treatment against n-vivo Gram-negative bacteria infections even be used orally, topically, or subcutaneously injected.

کلیدواژه‌ها [English]

  • Bacteriophage
  • Gram-negative bacteria
  • Infection
  • Systematic Review

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مجله دانشکده پزشکی اصفهان
دوره 37، شماره 524 - شماره پیاپی 524
خرداد و تیر 1398
صفحه 427-434

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سابقه مقاله

  • تاریخ دریافت: 03 اردیبهشت 1398
  • تاریخ بازنگری: 11 آبان 1403
  • تاریخ پذیرش: 17 فروردین 1401

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