The Relationship between Serum Level of Vitamin D and Depression Severity with Sexual Function in a Sample of Iranian Women in the Year 2017

Document Type : Original Article (s)

Authors

1 MSc Student, Department of Midwifery and Reproductive Health, Students Research Committee, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2 Assistant Professor, Department of Midwifery and Reproductive Health, School of Nursing and Midwifery AND Midwifery and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3 Assistant Professor, Department of Biostatistics, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran

4 Professor, Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran

Abstract

Background: Few available studies suggest the possible role of vitamin D deficiency in sexual dysfunction. The relationship between vitamin D deficiency and depression is still considered challenging issue. According to the bilateral relationship between depression and sexual dysfunction, this study aimed to determine the relationship of serum level of vitamin D and depression severity with sexual function in a sample of Iranian women with sexual dysfunction in the year 2017.Methods: This cross-sectional study was conducted on 85 women diagnosed for sexual dysfunction [Female sexual Function Index (FSFI) score of less than 28] and selected via convenience sampling method at selected health centers of Shahid Beheshti University of Medical Sciences, Tehran, Iran, in 2017. Research instruments were demographic questionnaire, Female Sexual Function Index, and Beck's Depression Inventory-II (BDI-II). Serum level of 25-hydroxy vitamin D was measured via electrochemiluminescence (ECL) method. Data were analyzed using Pearson’s correlation and linear regression tests via SPSS software.Findings: From all sexual response domains, arousal (r = 0.22), lubrication (r = 0.31), and sexual satisfaction (r = 0.27) domain scores and total FSFI score (r = 0.23) were directly correlated with the serum level of vitamin D (P < 0.05). Desire (r = 0.42), arousal (r = 0.32), lubrication (r = 0.31), and sexual satisfaction (r = 0.28) domain scores and total FSFI score (r = 0.3) were indirectly correlated with depression score (P < 0.01). Linear regression test showed that the levels of serum vitamin D and depression severity predicted sexual dysfunction (P < 0.05).Conclusion: It is appeared that there is a correlation between serum level of vitamin D and depression severity with sexual function. Broader analytical studies to identify possible causal relationship are suggested.

Keywords

References

  1. Sadock BJ, Sadock VA. Kaplan and Sadock's synopsis of psychiatry: Behavioral sciences/clinical psychiatry. 11th ed. Philadelphia, PA: Lippincott Williams and Wilkins; 2007.
  2. Berek JS. Berek and Novak's gynecology. 15th ed. Philadelphia, PA: Lippincott Williams and Wilkins; 2011. p. 270-320.
  3. Mazinani R, Akbari Mehr M, Kaskian A, Kashanian M. Evaluation of prevalence of sexual dysfunctions and its related factors in women. Razi J Med Sci 2012; 19(105): 61-8. [In Persian].
  4. Safarinejad MR. Female sexual dysfunction in a population-based study in Iran: prevalence and associated risk factors. Int J Impot Res 2006; 18(4): 382-95.
  5. Ramezani TF, Farahmand M, Simbar M, Malek AH. Factors associated with sexual dysfunction; a population based study in Iranian reproductive age women. Arch Iran Med 2014; 17(10): 679-84.
  6. Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr 2004; 80(6 Suppl): 1678S-88S.
  7. Bouillon R. From photosynthesis, metabolism, and action to clinical applications. Philadelphia, PA: Elsevier; 2010.
  8. Kinuta K, Tanaka H, Moriwake T, Aya K, Kato S, Seino Y. Vitamin D is an important factor in estrogen biosynthesis of both female and male gonads. Endocrinology 2000; 141(4): 1317-24.
  9. Nabizade-Asl L, Mozaffari-Khosravi H, Yassini-Ardekani S, Hadi Nodoushan H, Fallahzadeh H. Vitamin D status in patients with depression referred to specialized clinics affiliated to Shahid Sadoughi University of Medical Sciences, Yazd-2011. Toloo e Behdasht 2012; 11(1): 9-19. [In Persian].
  10. Tadayon M, Rad P, Abbaspour M, Latifi S, Rashidi I, Barati M et al. the effect of vitamin d suppository on atrophic vaginal mucosa in menopausal women. Armaghane-danesh 2012; 17(3): 187-95. [In Persian].
  11. Jablonski KL, Chonchol M, Pierce GL, Walker AE, Seals DR. 25-Hydroxyvitamin D deficiency is associated with inflammation-linked vascular endothelial dysfunction in middle-aged and older adults. Hypertension 2011; 57(1): 63-9.
  12. Hashemipour S, Larijani B, Adibi H, Javadi E, Sedaghat M, Pajouhi M, et al. Vitamin D deficiency and causative factors in the population of Tehran. BMC Public Health 2004; 4: 38.
  13. Azizi F, Raeiszadeh F, Mir Saeid Ghazi AS. Vitamin D deficiency in Tehran urban population. Pajouhesh Dar Pezeshki 2001; 24(4): 291-304. [In Persian].
  14. Heshmat R, Mohammad K, Majdzadeh SR, Forouzanfar MH, Bahrami A, Ranjbar Omrani GH, et al. Vitamin D deficiency in Iran: A multi-center study among different urban areas. Iran J Public Health 2008; 37(Suppl): 72-8.
  15. Ito TY, Trant AS, Polan ML. A double-blind placebo-controlled study of ArginMax, a nutritional supplement for enhancement of female sexual function. J Sex Marital Ther 2001; 27(5): 541-9.
  16. Ito TY, Polan ML, Whipple B, Trant AS. The enhancement of female sexual function with ArginMax, a nutritional supplement, among women differing in menopausal status. J Sex Marital Ther 2006; 32(5): 369-78.
  17. Krysiak R, Gilowska M, Okopien B. Sexual function and depressive symptoms in young women with low vitamin D status: a pilot study. Eur J Obstet Gynecol Reprod Biol 2016; 204: 108-12.
  18. Barassi A, Pezzilli R, Colpi GM, Corsi Romanelli MM, Melzi d'Eril GV. Vitamin D and erectile dysfunction. J Sex Med 2014; 11(11): 2792-800.
  19. Jorde R, Sneve M, Figenschau Y, Svartberg J, Waterloo K. Effects of vitamin D supplementation on symptoms of depression in overweight and obese subjects: randomized double blind trial. J Intern Med 2008; 264(6): 599-609.
  20. Anglin RE, Samaan Z, Walter SD, McDonald SD. Vitamin D deficiency and depression in adults: systematic review and meta-analysis. Br J Psychiatry 2013; 202: 100-7.
  21. McCabe M, Althof SE, Assalian P, Chevret-Measson M, Leiblum SR, Simonelli C, et al. Psychological and interpersonal dimensions of sexual function and dysfunction. J Sex Med 2010; 7(1 Pt 2): 327-36.
  22. Rosen R, Brown C, Heiman J, Leiblum S, Meston C, Shabsigh R, et al. The Female Sexual Function Index (FSFI): A multidimensional self-report instrument for the assessment of female sexual function. J Sex Marital Ther 2000; 26(2): 191-208.
  23. Lorenz TA, Meston CM. Associations among childhood sexual abuse, language use, and adult sexual functioning and satisfaction. Child Abuse Negl 2012; 36(2): 190-9.
  24. Mirghafourvand M, ohammad Alizadeh Charandabi S, Asghari Jafarabadi M, Tavananezhad N, Karkhane M. Socio demographic predictors of marital satisfaction in women of reproductive age, Tabriz, Iran, 2013. Iran J Obstet Gynecol Infertil 2013; 16(72): 1-12. [In Persian].
  25. Mohammadi K, Heydari M, Faghihzadeh S. The Female Sexual Function Index (FSFI): validation of the Iranian version. Payesh Health Monit 2008; 7(3): 269-78. [In Persian].
  26. Beck AT, Steer RA, Brown GK. Beck Depression Inventory-II. 2nd ed. San Antonio, TX: Psychological Corporation; 1996. p. 490-6.
  27. Dabson KS, Mohammad Khani P. Psychometric characteristics of Beck Depression Inventory–II in patients with major depressive disorder. J Rehab 2007; 8(Suppl): 82-8. [In Persian].
  28. Zare Bargabadi M, Taghiloo S, Kakavand AR. The relationship between the anxiety and depression with the mediation of referential thinking and perfectionism: Structural equation meth. J Fundam Ment Health 2016; 18(75): 455-64. [In Persian].
  29. Kidir V, Altuntas A, Inal S, Akpinar A, Orhan H, Sezer MT. Sexual dysfunction in dialysis patients: does vitamin D deficiency have a role? Int J Clin Exp Med 2015; 8(12): 22491-6.
  30. Canat M, Canat L, Ozturk FY, Eroglu H, Atalay HA, Altuntas Y. Vitamin D3 deficiency is associated with female sexual dysfunction in premenopausal women. Int Urol Nephrol 2016; 48(11): 1789-95.
  31. Tarcin O, Yavuz DG, Ozben B, Telli A, Ogunc AV, Yuksel M, et al. Effect of vitamin D deficiency and replacement on endothelial function in asymptomatic subjects. J Clin Endocrinol Metab 2009; 94(10): 4023-30.
  32. Lv WS, Zhao WJ, Gong SL, Fang DD, Wang B, Fu ZJ, et al. Serum 25-hydroxyvitamin D levels and peripheral neuropathy in patients with type 2 diabetes: a systematic review and meta-analysis. J Endocrinol Invest 2015; 38(5): 513-8.
  33. Hoogendijk WJ, Lips P, Dik MG, Deeg DJ, Beekman AT, Penninx BW. Depression is associated with decreased 25-hydroxyvitamin D and increased parathyroid hormone levels in older adults. Arch Gen Psychiatry 2008; 65(5): 508-12.
Journal of Isfahan Medical School
Volume 35, Issue 430 - Serial Number 430
March and April 2017
Pages 558-564

Files

History

  • Receive Date: 25 April 2017
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

Share

How to cite

Statistics