تأثیر نالوکسان بر طول مدت بستری ناشی از مسمومیت ترامادول: یک مطالعه‌ی‌ مقطعی آینده‌نگر

نوع مقاله : مقاله های پژوهشی

نویسندگان

1 پزشک عمومی، بخش اورژانس، دانشگاه علوم پزشکی البرز، کرج، ایران

2 متخصص پزشک قانونی و فلوشیپ سم‌شناسی بالینی، استادیار دانشگاه علوم پزشکی البرز مرکز توکسیکولوژی کوثر، البرز، کرج، ایران

3 هیأت علمی طب اورژانس و مسمومیت‌ها، دانشگاه علوم پزشکی البرز، کرج، ایران

4 استادیار، متخصص طب اورژانس، واحد توسعه تحقیقات بالینی رجایی، دانشگاه علوم پزشکی البرز، کرج، ایران

5 متخصص طب اورژانس، دانشگاه علوم پزشکی البرز، کرج، ایران

10.48305/jims.v42.i759.0168

چکیده

مقاله پژوهشی




مقدمه: این مطالعه به بررسی تأثیر نالوکسان بر طول مدت بستری ناشی از مسمومیت ترامادول پرداخت.
روش‌ها: جامعه‌ی مورد بررسی شامل کلیه‌ی بیماران دچار مسمومیت دارویی ترامادول بستری شده در بیمارستان کوثر کرج طی سال ۱۴۰۱ بود. حجم نمونه 100 نفر بود. داده‌های پژوهش به کمک پرسش‌نامه‌ی محقق ساخته برای جمع‌آوری اطلاعات دموگرافیک و اطلاعات بستری بیماران جمع‌آوری و مورد بررسی و مطالعه‌ی آماری قرار گرفتند.
یافته‌ها: میانگین سنی بیماران 6/801 ± 84/26 سال بود. 50 درصد از موارد پذیرش شده در مطالعه با قصد خودکشی دچار مسمومیت ترامادول شده بودند. میانگین دوز نالوکسان تجویز شده برای بیماران از مقدار 0/4 تا 2 برابر با 0/3855 ± 0/552 میلی‌گرم بود. در بررسی تظاهرات بالینی بیماران، در میان بیماران بستری شده 8 درصد با علایم بروز تشنج و 9 درصد با علایم دپرسیون تنفسی پذیرش شدند. میانگین مدت زمان بستری بیماران 991/991 ± 36/31 ساعت بود. بین بروز دپرسیون تنفسی و دوز نالوکسان، ارتباط معنی‌داری وجود داشت و با افزایش دوز تزریقی احتمال بروز دپرسیون کاهش می‌یافت (0/001 = P). در ارتباط با متغیر مدت زمان بستری نیز نتایج نشان داد که با وجود اختلاف معنی‌دار با دوز نالوکسان، دوزهای بالاتر نیاز به مدت زمان بستری بیشتری داشته‌اند (0/001 = P).
نتیجه‌گیری: مدت زمان بستری در بیمارستان و همچنین دپرسیون تنفسی حاصل از مسمومیت با ترامادول را می‌توان به طور مؤثری با استفاده از نالوکسان به حداقل رساند. بیشتر مسمومیت‌ها در جوانان و با هدف خودکشی صورت گرفته بود، به نظر می‌رسد آگاهی‌بخشی به آنان در مورد مصرف ترامادول ضروریست.

تازه های تحقیق

مریم فدایی دشتی: Google Scholar, PubMed

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The Effect of Naloxone on the Duration of Hospitalization Caused by Tramadol Poisoning: A Retrospective Cross-Sectional Study

نویسندگان [English]

  • Ali Ghaderimanesh 1
  • Hoorvash Farajidana 2
  • Mohammad Reza Maghsoudi 3
  • Maryam Fadaie Dashti 4
  • Akram Razavizadeh 5
1 General Practitioner, Department of Emergency, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
2 Association Professor, Clinical Toxicology Fellowship, Department of Clinical Toxicology, Kosar Hospital Poison Center, Emergency Department Alborz University of Medical Sciences, Karaj, Iran
3 Faculty of Emergency Medicine, Department of Emergency Medicine and Toxicology, Emergency Department Alborz University of Medical Sciences, Karaj, Iran
4 Association Professor, Department of Emergency Medicine and Toxicology, Rajaee Hospital Emergency Department, Alborz University of Medical Sciences, Karaj,
5 Faculty of Emergency Medicine, Department of Emergency, School of Medicine and Toxicology, Alborz University of Medical Sciences, Karaj, Iran
چکیده [English]

Background: This study examined the effect of naloxone on the duration of hospitalization caused by
tramadol poisoning.
Methods: The studied population included all patients with tramadol drug poisoning admitted to Kowsar Karaj Hospital in 2022. The sample size was 100 people. The research data were collected with the help of a questionnaire made by the researcher to collect demographic information and hospitalization information of the patients and were analyzed and studied statistically.
Findings: The average age of patients was 26.84 ± 6.801 years. 50% of the cases admitted to the study with suicidal intent were poisoned by tramadol. The average dose of naloxone prescribed for the patients was
0.552 ± 0.3855 mg. In the examination of the clinical manifestations of the patients, among the hospitalized patients, 8% were admitted with symptoms of seizures and 9% with symptoms of respiratory depression. The average duration of hospitalization of patients was 36.31 ± 16.991 hours. There was a significant relationship between the occurrence of respiratory depression and the dose of naloxone, and with the increase of the injection dose, the probability of occurrence of depression decreased. (P = 0.001). Concerning the length of hospitalization variable, the results showed that despite the significant difference in the dose of naloxone, higher doses required. They had a longer hospital stay (P = 0.001).
Conclusion: The duration of hospital stays, as well as the respiratory depression caused by tramadol poisoning, can be effectively minimized by using naloxone. Most of the poisonings were done in young people to commit suicide. It seems that it is necessary to inform them about the use of tramadol.

کلیدواژه‌ها [English]

  • Naloxone
  • Tramadol
  • Poisoning
  • Duration of hospitalization

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مجله دانشکده پزشکی اصفهان
دوره 42، شماره 759
هفته 3، اردیبهشت
فروردین و اردیبهشت 1403
صفحه 168-175

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سابقه مقاله

  • تاریخ دریافت: 20 تیر 1402
  • تاریخ پذیرش: 19 خرداد 1403

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