Expression of Aromatase Protein in Abdominal Subcutaneous Adipose Tissue of Pregnant Women with Polycystic Ovary Syndrome (PCOS)

Document Type : Original Article (s)

Authors

1 PhD Student of Biochemistry, Department of Biology, School of Science, Science and Research Branch, Islamic Azad University, Tehran, Iran

2 Professor, Reproductive Epidemiology Research Center AND Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, Academic Center for Education, Culture and Research (ACECR), Tehran, Iran

3 Professor, Department of Biology, School of Science, Science and Research Branch, Islamic Azad University, Tehran, Iran

4 Assistant Professor, Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive, Academic Center for Education, Culture and Research (ACECR), Tehran, Iran

Abstract

Background: Polycystic ovary syndrome (PCOS) is one of the hormonal disorders in women. The PCOS may be due to decreased aromatase activity in adipose tissue. The aim of this study was to investigate the differences in the expression of aromatase protein in adipose tissue of pregnant women with and without PCOS.Methods: In this case-control study, aromatase protein expression were compared in subcutaneous adipose tissue of 11 pregnant women with and 11 without PCOS who were matched with each other in terms of weight characteristics before pregnancy and age. A subcutaneous adipose tissue samples (3-4 grams) was obtained during cesarean section. The expression of aromatase protein in adipose tissue was assessed using Western blotting method. All obtained data were statistically analyzed using SAS software. Findings: According to the analysis and quantification of the results, it was shown that the expression of aromatase protein in the subcutaneous adipose tissue of the abdomen of the group with PCOS decreased significantly compared to the non-PCOS group (P = 0.006). In other words, the expression of aromatase protein was about one-third lower in the adipose tissue of women with PCOS than in women without it.Conclusion: The current study shows that the expression of aromatase protein in the adipose tissue of women with PCOS is reduced. This finding could confirm the key role of adipose tissue in the development of symptoms of this syndrome.

Keywords

References

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Journal of Isfahan Medical School
Volume 38, Issue 589 - Serial Number 589
July and August 2020
Pages 621-627

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History

  • Receive Date: 15 April 2020
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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