تأثیر مکمل کیوتن در ناباروری مردان: یک مرور سیستماتیک بر روی مطالعات کارآزمایی بالینی

نوع مقاله : مقاله مروری

نویسندگان

1 دانشجوی کارشناسی ارشد، گروه علوم بهداشتی در تغذیه، دانشکده‌ی تغذیه و علوم غذایی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

2 گروه تغذیه، دانشکده‌ی تغذیه و علوم غذایی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

3 دانشیار، گروه تغذیه‌ی جامعه، دانشکده‌ی تغذیه و علوم غذایی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

چکیده

مقدمه: ناباروری به عنوان عدم بارداری به دنبال داشتن رابطه‌ی جنسی در مدت حداقل یک سال در صورت عدم استفاده از هر گونه روش پیش‌گیری از بارداری تعریف می‌شود و ۱۵ درصد از افراد دنیا را درگیر کرده است که ۷۰-۲۰ درصد از موارد آن مربوط به مردان می‌باشد. مطالعات نشان می‌دهند که ناباروری با کاهش سطح کیوتن در سرم و مایع سمینال همراه است و دریافت مکمل آن، می‌تواند باعث کاهش علایم ناباروری و بهبود آن شود.روش‌ها: هدف از انجام مطالعه‌ی حاضر، مروری بر پژوهش‌های انجام گرفته برای بررسی رابطه‌ی کیوتن و ناباروری می‌باشد. مطالعات انجام شده‌ی مرتبط با اثر دریافت مکمل کیوتن بر ناباروری مردان از پایگاه‌های PubMed، Scopus، ISI و Google Scholar بین سال‌های 2017-2000 با کلید واژه‌های Coenzyme Q10، Ubiquinol-10، Infertility، Male Infertility، Male fertility problems، Semen parameters، Sexual dysfunction مورد بررسی قرار گرفتند.یافته‌ها: در بیشتر مطالعات کارآزمایی بالینی، مکمل کیوتن اثر مثبتی بر خصوصیات اسپرم از جمله غلظت، ریخت‌شناسی و حرکت داشت و همچنین، کاهش تخریب DNA را به همراه داشت. همچنین، سطح آنزیم‌های آنتی‌اکسیدانی کاتالاز و سوپراکسید دیسموتاز و همین‌طور، ظرفیت تام آنتی‌اکسیدانی نسبت به قبل از مداخله افزایش معنی‌داری داشت. با این وجود، برخی مطالعات اثر معنی‌داری از مکمل کیوتن بر خصوصیات اسپرم یافت نکردند.نتیجه‌گیری: در بیشتر مطالعات، تأثیر مثبت مکمل کیوتن بر روی پارامترهای اسپرمی، آسیب DNA، ظرفیت آنتی‌اکسیدانی و آنزیم‌‌های آنتی‌اکسیدانی اثبات شده است، اما به دلیل کم بودن مطالعات، انجام مطالعات کارآزمایی بیشتری در این زمینه لازم است.

کلیدواژه‌ها

عنوان مقاله [English]

The Effect of Coenzyme Q10 Supplementation on Male Infertility: A Systematic Review on Randomized Clinical Trial Studies

نویسندگان [English]

  • Mehran Nouri 1
  • Keyhan Lotfi 2
  • Gholamreza Askari 3
1 MSc Student, Department of Health Sciences in Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
3 Associate Professor, Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده [English]

Background: Infertility is defined as failure in fertility after having sex for at least one year, if no contraceptive method is used, and 15% of the world's population is involved, of which 20-70 percent is related to men. Studies show that infertility is associated with a decrease in Q10 levels in the serum and seminal fluid, and its supplementation can reduce the symptoms of infertility, and improve it as well.Methods: The purpose of this study was to review the research done to investigate the relationship between Q10 and infertility. Clinical trial studies on the effect of supplementation of Q10 on male infertility from PubMed, Scopus, ISI, and Google Scholar databases between 2000 and 2017 were assessed using the keywords of coenzyme Q10, ubiquinol-10, infertility, male infertility, male fertility problems, semen parameters, sexual dysfunction.Findings: In most clinical trial studies, supplementation of Q10 had a positive effect on sperm parameters such as concentration, morphology, and movement. DNA fragmentation was also reduced; moreover, antioxidant enzymes of catalase and superoxide dismutase as well as total antioxidant capacity were significantly higher than before the intervention. However, some studies found no significant effect of Q10 on the sperm parameters.Conclusion: In most studies, the positive effects of Q10 supplement on sperm parameters, DNA damage, antioxidant capacity, and antioxidant enzymes have been proven, but due to the lack of studies, more clinical trial studies are needed in this area.

کلیدواژه‌ها [English]

  • Ceonzyme Q10
  • Ubiquinol-10
  • Fertility
  • Infertility
  • Male
  • Sperm
  • Sexual dysfunction
  • Physiological

مراجع

  1. Chirputkar R, Vaidya A. Understanding infertility and the potential role of stem cells in infertility treatment: A short communication. Int J Reprod Fertil Sex Health 2015; 2(1): 37-40.
  2. Zegers-Hochschild F, Adamson GD, de Mouzon J, Ishihara O, Mansour R, Nygren K, et al. The International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) Revised Glossary on ART Terminology, 2009. Human Reproduction 2009; 24(11): 2683-7.
  3. Bushnik T, Cook JL, Yuzpe AA, Tough S, Collins J. Estimating the prevalence of infertility in Canada. Hum Reprod 2012; 27(3): 738-46.
  4. Agarwal A, Mulgund A, Hamada A, Chyatte MR. A unique view on male infertility around the globe. Reprod Biol Endocrinol 2015; 13: 37.
  5. Colaco S, Modi D. Genetics of the human Y chromosome and its association with male infertility. Reprod Biol Endocrinol 2018; 16(1): 14.
  6. Ezi S, Hosseini M, Hassanzadeh-Taheri M, Jahani F, Afshar M, Hassanzadeh-Taheri M. Effects of tail fat enriched diet on male Wistar rat reproductive system. J Birjand Univ Med Sci 2016; 23(1): 1-10. [In Persian].
  7. Tafvizi F, Baghdadi K, Hayati Roodbari N. Lack of relatedness between Human cytomegalovirus in semen and male infertility. Iran J Med Microbiol 2016; 10(3): 39-46. [In Persian].
  8. Zare Z, Golmakani N, Shareh H, Shakeri Mt, Khadem N. Factors related to marital satisfaction in primiparous women during postpartum period. J Midwifery Reprod Health 2014; 2(2): 120-7.
  9. Adewoyin M, Ibrahim M, Roszaman R, Isa MLM, Alewi NAM, Rafa AAA, et al. Male infertility: The effect of natural antioxidants and phytocompounds on seminal oxidative stress. Diseases 2017; 5(1): 9.
  10. Hotaling J, Carrell DT. Clinical genetic testing for male factor infertility: Current applications and future directions. Andrology 2014; 2(3): 339-50.
  11. La Vignera S, Condorelli R, Vicari E, D'Agata R, Calogero AE. Diabetes mellitus and sperm parameters. J Androl 2012; 33(2): 145-53.
  12. Showell MG, Brown J, Yazdani A, Stankiewicz MT, Hart RJ. Antioxidants for male subfertility. Cochrane Database Syst Rev 2011; (1): CD007411.
  13. Moradi M, Haghighatdoost F, Feizi A, Azadbakht L. Effect OF co-Q10 supplementation on fasting blood glucose, fasting insulin and HBA1C; a systematic review and meta-analysis study. Iran J Diabetes Lipid Disord 2017; 15(3): 158-71. [In Persian].
  14. Pahari SK, Ghosh S, Halder S, Jana M. Role of coenzyme Q10 in human life. Research J Pharm Tech 2016; 9(6): 635-40.
  15. Lim SC, Tan HH, Goh SK, Subramaniam T, Sum CF, Tan IK, et al. Oxidative burden in prediabetic and diabetic individuals: Evidence from plasma coenzyme Q(10). Diabet Med 2006; 23(12): 1344-9.
  16. Hathcock JN, Shao A. Risk assessment for coenzyme Q10 (Ubiquinone). Regul Toxicol Pharmacol 2006; 45(3): 282-8.
  17. Lee BJ, Huang YC, Chen SJ, Lin PT. Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with coronary artery disease. Nutrition 2012; 28(3): 250-5.
  18. Mohammadi-Bardbori A, Hosseini MJ. Therapeutic implication of coenzyme Q10 during statin therapy: pros and cons. Trends in Pharmaceutical Sciences 2015; 1(3): 119-28.
  19. Sanoobar M, Dehghan P, Khalili M, Azimi A, Seifar F. Coenzyme Q10 as a treatment for fatigue and depression in multiple sclerosis patients: A double blind randomized clinical trial. Nutr Neurosci 2016; 19(3): 138-43.
  20. Ahmadi S, Bashiri R, Ghadiri-Anari A, Nadjarzadeh A. Antioxidant supplements and semen parameters: An evidence based review. Int J Reprod Biomed (Yazd) 2016; 14(12): 729-36.
  21. Balercia G, Buldreghini E, Vignini A, Tiano L, Paggi F, Amoroso S, et al. Coenzyme Q10 treatment in infertile men with idiopathic asthenozoospermia: A placebo-controlled, double-blind randomized trial. Fertil Steril 2009; 91(5): 1785-92.
  22. Safarinejad MR, Safarinejad S, Shafiei N, Safarinejad S. Effects of the reduced form of coenzyme Q10 (ubiquinol) on semen parameters in men with idiopathic infertility: A double-blind, placebo controlled, randomized study. J Urol 2012; 188(2): 526-31.
  23. Lafuente R, Gonzalez-Comadran M, Sola I, Lopez G, Brassesco M, Carreras R, et al. Coenzyme Q10 and male infertility: A meta-analysis. J Assist Reprod Genet 2013; 30(9): 1147-56.
  24. Balercia G, Mosca F, Mantero F, Boscaro M, Mancini A, Ricciardo-Lamonica G, et al. Coenzyme Q(10) supplementation in infertile men with idiopathic asthenozoospermia: an open, uncontrolled pilot study. Fertil Steril 2004; 81(1): 93-8.
  25. Safarinejad MR. Efficacy of coenzyme Q10 on semen parameters, sperm function and reproductive hormones in infertile men. J Urol 2009; 182(1): 237-48.
  26. Safarinejad MR. The effect of coenzyme Q(1)(0) supplementation on partner pregnancy rate in infertile men with idiopathic oligoasthenoteratozoospermia: An open-label prospective study. Int Urol Nephrol 2012; 44(3): 689-700.
  27. Abad C, Amengual MJ, Gosalvez J, Coward K, Hannaoui N, Benet J, et al. Effects of oral antioxidant treatment upon the dynamics of human sperm DNA fragmentation and subpopulations of sperm with highly degraded DNA. Andrologia 2013; 45(3): 211-6.
  28. Nadjarzadeh A, Shidfar F, Amirjannati N, Vafa MR, Motevalian SA, Gohari MR, et al. Effect of Coenzyme Q10 supplementation on antioxidant enzymes activity and oxidative stress of seminal plasma: a double-blind randomised clinical trial. Andrologia 2014; 46(2): 177-83.
  29. Festa R, Giacchi E, Raimondo S, Tiano L, Zuccarelli P, Silvestrini A, et al. Coenzyme Q10 supplementation in infertile men with low-grade varicocele: an open, uncontrolled pilot study. Andrologia 2014; 46(7): 805-7.
  30. Cakiroglu B, Eyyupoglu SE, Gozukucuk R, Uyanik BS. Ubiquinol effect on sperm parameters in subfertile men who have astheno-teratozoospermia with normal sperm concentration. Nephrourol Mon 2014; 6(3): e16870.
  31. Thakur AS, Littarru GP, Funahashi I, Painkara US, Dange NS, Chauhan P. Effect of Ubiquinol Therapy on Sperm Parameters and Serum Testosterone Levels in Oligoasthenozoospermic Infertile Men. J Clin Diagn Res 2015; 9(9): BC01-BC03.
  32. Lipovac M, Bodner F, Imhof M, Chedraui P. Comparison of the effect of a combination of eight micronutrients versus a standard mono preparation on sperm parameters. Reprod Biol Endocrinol 2016; 14(1): 84.
  33. Farsi F, Mohammadshahi M, Alavinejad P, Rezazadeh A, Zarei M, Engali KA. Functions of coenzyme Q10 supplementation on liver enzymes, markers of systemic inflammation, and adipokines in patients affected by nonalcoholic fatty liver disease: A double-blind, placebo-controlled, randomized clinical trial. J Am Coll Nutr 2016; 35(4): 346-53.
  34. Bentov Y, Esfandiari N, Burstein E, Casper RF. The use of mitochondrial nutrients to improve the outcome of infertility treatment in older patients. Fertil Steril 2010; 93(1): 272-5.
  35. Garrido-Maraver J, Cordero MD, Oropesa-Avila M, Vega AF, de la Mata M, Pavon AD, et al. Clinical applications of coenzyme Q10. Front Biosci (Landmark Ed) 2014; 19: 619-33.
  36. Mishra S, Dash AK, Kumar S. Hundred problems, one solution asparagus racemosus. World Journal of Pharmaceutical Research 2014; 3(1): 201-11..
  37. Agarwal A, Makker K, Sharma R. Clinical relevance of oxidative stress in male factor infertility: An update. Am J Reprod Immunol 2008; 59(1): 2-11.
  38. Misro MM, Choudhury L, Upreti K, Gautam D, Chaki SP, Mahajan AS, et al. Use of hydrogen peroxide to assess the sperm susceptibility to oxidative stress in subjects presenting a normal semen profile. Int J Androl 2004; 27(2): 82-7.
  39. Khosrowbeygi A, Zarghami N. Seminal plasma levels of free 8-isoprostane and its relationship with sperm quality parameters. Indian J Clin Biochem 2008; 23(1): 49-52.
  40. Eroglu M, Sahin S, Durukan B, Ozakpinar OB, Erdinc N, Turkgeldi L, et al. Blood serum and seminal plasma selenium, total antioxidant capacity and coenzyme q10 levels in relation to semen parameters in men with idiopathic infertility. Biol Trace Elem Res 2014; 159(1-3): 46-51.
  41. Mancini A, Festa R, Silvestrini A, Nicolotti N, Di Donna V, La Torre G, et al. Hormonal regulation of total antioxidant capacity in seminal plasma. J Androl 2009; 30(5): 534-40.
  42. Mancini A, Milardi D, Bianchi A, Festa R, Silvestrini A, De ML, et al. Increased total antioxidant capacity in seminal plasma of varicocele patients: A multivariate analysis. Arch Androl 2007; 53(1): 37-42.
  43. Roychoudhury S, Sharma R, Sikka S, Agarwal A. Diagnostic application of total antioxidant capacity in seminal plasma to assess oxidative stress in male factor infertility. J Assist Reprod Genet 2016; 33(5): 627-35.
  44. Liu HT, Huang YC, Cheng SB, Huang YT, Lin PT. Effects of coenzyme Q10 supplementation on antioxidant capacity and inflammation in hepatocellular carcinoma patients after surgery: A randomized, placebo-controlled trial. Nutr J 2016; 15(1): 85.
  45. Maheshwari RA, Balaraman R, Sen AK, Seth AK. Effect of coenzyme Q10 alone and its combination with metformin on streptozotocin-nicotinamide-induced diabetic nephropathy in rats. Indian J Pharmacol 2014; 46(6): 627-32.
  46. Ghanbarzadeh S, Garjani A, Ziaee M, Khorrami A. CoQ10 and L-carnitine attenuate the effect of high LDL and oxidized LDL on spermatogenesis in male rats. Drug Res (Stuttg ) 2014; 64(10): 510-5.
  47. Cavallini G. Male idiopathic oligoasthenoteratozoospermia. Asian J Androl 2006; 8(2): 143-57.
  48. Barekat F, Tavalaee M, Azadi L, Nasr-Esfahani MH. Comparison of sperm parameters and its functional characteristics between fertile and infertile men with varicocele. Journal of Cell and Tissue 2016; 6(4): 523-32. [In Persian].
  49. Ross C, Morriss A, Khairy M, Khalaf Y, Braude P, Coomarasamy A, et al. A systematic review of the effect of oral antioxidants on male infertility. Reprod Biomed Online 2010; 20(6): 711-23.
  50. Talevi R, Barbato V, Fiorentino I, Braun S, Longobardi S, Gualtieri R. Protective effects of in vitro treatment with zinc, d-aspartate and coenzyme q10 on human sperm motility, lipid peroxidation and DNA fragmentation. Reprod Biol Endocrinol 2013; 11: 81.
  51. Meseguer M, Santiso R, Garrido N, Garcia-Herrero S, Remohi J, Fernandez JL. Effect of sperm DNA fragmentation on pregnancy outcome depends on oocyte quality. Fertil Steril 2011; 95(1): 124-8.
  52. Mahfouz R, Sharma R, Thiyagarajan A, Kale V, Gupta S, Sabanegh E, et al. Semen characteristics and sperm DNA fragmentation in infertile men with low and high levels of seminal reactive oxygen species. Fertil Steril 2010; 94(6): 2141-6.
  53. Wathes DC, Abayasekara DR, Aitken RJ. Polyunsaturated fatty acids in male and female reproduction. Biol Reprod 2007; 77(2): 190-201.
  54. Hosen MB, Islam MR, Begum F, Kabir Y, Howlader MZ. Oxidative stress induced sperm DNA damage, a possible reason for male infertility. Iran J Reprod Med 2015; 13(9): 525-32.
  55. Greco E, Iacobelli M, Rienzi L, Ubaldi F, Ferrero S, Tesarik J. Reduction of the incidence of sperm DNA fragmentation by oral antioxidant treatment. J Androl 2005; 26(3): 349-53.
  56. Menezo YJ, Hazout A, Panteix G, Robert F, Rollet J, Cohen-Bacrie P, et al. Antioxidants to reduce sperm DNA fragmentation: An unexpected adverse effect. Reprod Biomed Online 2007; 14(4): 418-21.
  57. Garcia-Peiro A, Martinez-Heredia J, Oliver-Bonet M, Abad C, Amengual MJ, Navarro J, et al. Protamine 1 to protamine 2 ratio correlates with dynamic aspects of DNA fragmentation in human sperm. Fertil Steril 2011; 95(1): 105-9.
مجله دانشکده پزشکی اصفهان
دوره 36، شماره 504 - شماره پیاپی 504
آذر و دی 1397
صفحه 1401-1407

فایل ها

سابقه مقاله

  • تاریخ دریافت: 24 تیر 1397
  • تاریخ بازنگری: 12 آبان 1403
  • تاریخ پذیرش: 17 فروردین 1401

هم رسانی

ارجاع به این مقاله

آمار