The Association between Angiogenesis and Pathological Stage in Colon Adenocarcinoma Based on Immunohistochemical CD34 Staining

Authors

1 Assistant Professor, Department of Pathology, School of Medicine AND Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iran

2 - Associate Professor, Department of Pathology, School of Medicine AND Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iran

3 Assistant Professor, Department of Surgery, School of Medicine AND Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iran

4 Department of Pathology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

Abstract

Background: Finding non-invasive methods in predicting pathological stage is important for more accurate
prognosis and treatment-related decision-making. In this study, using immunohistochemical CD34 staining, the
association between the rate of angiogenesis and tumor pathological stage was examined in colon adenocarcinoma.
Methods: In this comparative cross-sectional study, 60 cases with colon adenocarcinoma admitted to Afzalipour
hospital in Kerman, Iran, between 2014 and 2016, were enrolled. Appropriates Paraffin blocks of tumoral tissue
were selected, and the mean number of vessels was determined through CD34 staining. The groups were then
compared in terms of the pathological stage of individual cases.
Findings: The mean number of vessels was 25.2 ± 8.9, and the minimum and maximum were 11 and 44,
respectively. The mean number of young vessels in 12 patients (20%) was mild, in 29 patients (48.3%) was
moderate, and in 19 patients (31.7%) was severe category. ANOVA test demonstrated that the number of new
vessels was significantly lower in cases at lower stages.
Conclusion: Significant reverse association was observed between the rate of angiogenesis and pathological
stage. Therefore, the number of young vessels created in the tumor can probably be one of the predictors of
pathologic stage.

Keywords

References

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Journal of Isfahan Medical School
Volume 39, Issue 656
November and December 2022
Pages 1017-1023

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History

  • Receive Date: 03 April 2022
  • Accept Date: 03 April 2022

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