Evaluation between Fat Distribution in Abdominal CT Scan with Some Physical and Biochemical Variable in Ischemic Patients: GAAMI Study

Document Type : Original Article(s)

Authors

1 Associate Professor, Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

2 Associate Professor, Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Department of Cardiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 Assistant Professor, Department of Radiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

4 Resident, Department of Radiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

5 Laboratory of Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

6 Department of Internal Medicine, Emam Hospital, Tehran University of Medical Sciences, Tehran, Iran.

7 Professor, Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

Abstract

Background: This study aimed to evaluate the relation between fat distribution in subcutaneous and visceral area with other variables in patients suffered for stable angina.Methods: This cross sectional study was done on 40-60 years patients with stable angina. CT scan was determined subcutaneous (deep and superficial) and visceral fat. Body mass index, waist circumference, and blood pressure measurement were calculated by standard protocols. Sugar, triglyceride, total cholesterol, LDL-c, HDL-c, Leptin and apolipoproteins A and B were recorded. Data was entered in SPSS15 and analyzed by Student-t and correlation test.Finding: Sixty-six men and 88 women were studied. The mean of BMI, apo A, Leptin, lipids variables were significantly different in two sexes. Total variable fat accumulation in women was greater than men (P < 0.05). The correlation was significant between weight, BMI, WC and Leptin level in both sexes.Conclusion: Relation of fat distributions and other risk factors was different in both sexes, but BMI and WC had significant correlation with CT scan variables.   

Keywords

References

  1. WRITING GROUP MEMBERS, Lloyd-Jones D, Adams RJ, Brown TM, Carnethon M, Dai S, et al. Heart disease and stroke statistics-2010 update: a report from the American Heart Association. Circulation 2010; 121(7): e46-e215.
  2. Fox CS, Evans JC, Larson MG, Kannel WB, Levy D. Temporal trends in coronary heart disease mortality and sudden cardiac death from 1950 to 1999: the Framingham Heart Study. Circulation 2004; 110(5):522-7.
  3. Tavassoli AA, Gharipour M, Khosravi A, Keli-shadi R, Dana Siadat Z, Bahonar A, et al. Gender differences in obesogenic behavior, socioeconomic and metabolic factors in a population based sample of Iranians: The IHHP Study. J Health Popul Nutr 2010; 28(6): 602-9.
  4. Fox CS, Massaro JM, Hoffmann U, Pou KM, Maurovich-Horvat P, Liu CY, et al. Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study. Circulation 2007; 116(1): 39-48.
  5. Caballero B. The global epidemic of obesity: an overview. Epidemiol Rev 2007; 29: 1-5.
  6. Zhu S, Wang Z, Heshka S, Heo M, Faith MS, Heymsfield SB. Waist circumference and obesity-associated risk factors among whites in the third National Health and Nutrition Examination Survey: clinical action thresholds. Am J Clin Nutr 2002; 76(4): 743-9.
  7. Ardern CI, Janssen I, Ross R, Katzmarzyk PT. Development of health-related waist circumference thresholds within BMI categories. Obes Res 2004; 12(7): 1094-103.
  8. Abate N, Garg A, Peshock RM, Stray-Gundersen J, Grundy SM. Relationships of generalized and regional adiposity to insulin sensitivity in men. J Clin Invest 1995; 96(1): 88-98.
  9. Björntorp P. "Portal" adipose tissue as a generator of risk factors for cardiovascular disease and diabetes. Arteriosclerosis 1990; 10(4): 493-6.
  10. Okamoto Y, Kihara S, Funahashi T, Matsuzawa Y, Libby P. Adiponectin: a key adipocytokine in metabolic syndrome. Clin Sci (Lond) 2006; 110(3): 267-78.
  11. Nielsen S, Guo Z, Johnson CM, Hensrud DD, Jensen MD. Splanchnic lipolysis in human obesity. J Clin Invest 2004; 113(11): 1582-8.
  12. Kanaya AM, Harris T, Goodpaster BH, Tylavsky F, Cummings SR; Health, Aging, and Body Composition (ABC) Study. Adipocytokines attenuate the association between visceral adiposity and diabetes in older adults. Diabetes Care 2004; 27(6): 1375-80.
  13. Bock G, Chittilapilly E, Basu R, Toffolo G, Cobelli C, Chandramouli V, et al. Contribution of hepatic and extrahepatic insulin resistance to the pathogenesis of impaired fasting glucose: role of increased rates of gluconeogenesis. Diabetes 2007; 56(6): 1703-11.
  14. Goodpaster BH, Krishnaswami S, Resnick H, Kelley DE, Haggerty C, Harris TB, et al. Association between regional adipose tissue distribution and both type 2 diabetes and impaired glucose tolerance in elderly men and women. Diabetes Care 2003; 26(2): 372-9.
  15. Bray GA, Jablonski KA, Fujimoto WY, Barrett-Connor E, Haffner S, Hanson RL, et al. Relation of central adiposity and body mass index to the development of diabetes in the Diabetes Prevention Program. Am J Clin Nutr 2008; 87(5): 1212-8.
  16. Tulloch-Reid MK, Hanson RL, Sebring NG, Reynolds JC, Premkumar A, Genovese DJ, et al. Both subcutaneous and visceral adipose tissue correlate highly with insulin resistance in african americans. Obes Res 2004; 12(8): 1352-9.
  17. Wagenknecht LE, Langefeld CD, Scherzinger AL, Norris JM, Haffner SM, Saad MF, et al. In-sulin sensitivity, insulin secretion, and abdominal fat: the Insulin Resistance Atherosclerosis Study (IRAS) Family Study. Diabetes 2003; 52(10): 2490-6.
  18. Hayashi T, Boyko EJ, Leonetti DL, McNeely MJ, Newell-Morris L, Kahn SE, et al. Visceral adiposity and the prevalence of hypertension in Japanese Americans. Circulation 2003; 108(14): 1718-23.
  19. Hayashi T, Boyko EJ, Leonetti DL, McNeely MJ, Newell-Morris L, Kahn SE, et al. Visceral adiposity is an independent predictor of incident hypertension in Japanese Americans. Ann Intern Med 2004; 140(12): 992-1000.
  20. Nicklas BJ, Penninx BW, Ryan AS, Berman DM, Lynch NA, Dennis KE. Visceral adipose tissue cutoffs associated with metabolic risk factors for coronary heart disease in women. Diabetes Care 2003; 26(5): 1413-20.
  21. Kobayashi H, Nakamura T, Miyaoka K, Nishida M, Funahashi T, Yamashita S, et al. Visceral fat accumulation contributes to insulin resistance, small-sized low-density lipoprotein, and progression of coronary artery disease in middle-aged non-obese Japanese men. Jpn Circ J 2001; 65(3): 193-9.
  22. Sam S, Haffner S, Davidson MH, D'Agostino RB Sr, Feinstein S, Kondos G, et al. Relationship of abdominal visceral and subcutaneous adipose tissue with lipoprotein particle number and size in type 2 diabetes. Diabetes 2008; 57(8): 2022-7.
  23. Goodpaster BH, Krishnaswami S, Harris TB, Katsiaras A, Kritchevsky SB, Simonsick EM, et al. Obesity, regional body fat distribution, and the metabolic syndrome in older men and women. Arch Intern Med 2005; 165(7): 777-83.
  24. Carr DB, Utzschneider KM, Hull RL, Kodama K, Retzlaff BM, Brunzell JD, et al. Intra-abdominal fat is a major determinant of the National Cholesterol Education Program Adult Treatment Panel III criteria for the metabolic syndrome. Diabetes 2004; 53(8): 2087-94.
  25. Lemieux S. Contribution of visceral obesity to the insulin resistance syndrome. Can J Appl Physiol 2001; 26(3): 273-90.
  26. Brochu M, Starling RD, Tchernof A, Matthews DE, Garcia-Rubi E, Poehlman ET. Visceral adipose tissue is an independent correlate of glucose disposal in older obese postmenopausal women. J Clin Endocrinol Metab 2000; 85(7): 2378-84.
  27. DeNino WF, Tchernof A, Dionne IJ, Toth MJ, Ades PA, Sites CK, et al. Contribution of ab-dominal adiposity to age-related differences in insulin sensitivity and plasma lipids in healthy nonobese women Diabetes Care 2001; 24(5): 925-32.
  28. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, et al. Seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure Hypertension 2003; 42(6): 1206-52.
  29. Siavash M, Sadeghi M, Salarifar F, Amini M, Shojaee-Moradie F. Comparison of Body Mass Index and Waist/Height ratio in predicting definite coronary artery disease. Ann Nutr Metab 2008; 53: 162-6.
  30. Deschenes D, Couture P, Dupont P, Tchernof A. Subdivision of the subcutaneous adipose tissue compartment and lipid-lipoprotein levels in women. Obesity Res 2003; 11: 469-76.
  31. Oka R, Miura K, Sakurai M, Nakamura K, Yagi K, Miyamoto S, et al. Impacts of visceral adipose tissue and subcutaneous adipose tissue on metabolic risk factors in middle-aged Japanese. Obesity (Silver Spring) 2010; 18(1): 153-60.
  32. Sundell J, Huupponen R, Raitakari OT, Nuutila P, Knuuti J. High serum leptin is associated with attenuated coronary vasoreactivity. Obes Res 2003; 11(6): 776-82.
  33. Cooke JP, Oka RK. Does leptin cause vascular disease? Circulation 2002; 106(15): 1904-5.
  34. Garg A. Regional adiposity and insulin resis-tance. J Clin Endocrinol Metab 2004; 89(9): 4206-10.
  35. Johnson D, Prud'homme D, Despres JP, Nadeau A, Tremblay A, Bouchard C. Relation of abdominal obesity to hyperinsulinemia and high blood pressure in men. Int J Obes Relat Metab Disord 1992; 16(11): 881-90.
  36. Vega GL, Adams-Huet B, Peshock R, Willett D, Shah B, Grundy SM. Influence of body fat content and distribution on variation in metabolic risk. J Clin Endocrinol Metab 2006; 91(11): 4459-66.
Journal of Isfahan Medical School
Volume 28, Issue 124 - Serial Number 124
November and December 2011
Pages 1943-1952

Files

History

  • Receive Date: 19 March 2011
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

Share

How to cite

Statistics