اثر پانسمان هیدروژل پلی‌وینیل پایرولیدون بر بهبود زخم باز در موش صحرایی

نوع مقاله : مقاله های پژوهشی

نویسندگان

1 دانشجوی کارشناسی ارشد، گروه زیست‌شناسی، دانشکده‌ی علوم، دانشگاه اصفهان، اصفهان، ایران

2 استادیار، گروه زیست‌شناسی، دانشکده‌ی علوم، دانشگاه اصفهان، اصفهان، ایران

3 دانشیار، گروه آسیب‌شناسی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

4 بیمارستان سوانح سوختگی اصفهان، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

چکیده

مقدمه: برای سال‌ها ترکیب‌ها و روش‌های مختلف برای بهبود زخم مورد استفاده قرار گرفته که برخی مؤثر و تعدادی بدون تأثیر و حتی مضر بوده است. پانسمان‌های جدید مانند هیدروژل، نتایج قابل توجهی در ترمیم زخم نشان داده است. هیدروژل به دلیل شفافیت، تبادل گازهای تنفسی و آب، جذب ترشحات زخم، تنظیم دمای سطح زخم، جلوگیری از عوامل عفونت‌زا و تعویض آسان مورد توجه قرار گرفته است. این پژوهش با هدف بررسی اثر پانسمان هیدروژل پلی‌وینیل پیرولیدون بر درمان زخم ایجاد شده در موش صحرایی انجام شد.روش‌ها: 30 موش صحرایی با وزن 20 ± 230 گرم به صورت نیمه‌تصادفی به گروه‌های ده‌تایی شاهد، درمان با تتراسایکلین و درمان با هیدروژل تقسیم شدند. پس از بی‌هوشی و تراشیدن محل، از پوست پشت هر حیوان قطعه‌ای به ابعاد cm 1 x 1 برداشته شد. دوره‌ی درمان 21 روزه در نظر گرفته شد و اندازه‌گیری سطح زخم در روزهای 0، 7،10، 14،17 و 21 انجام گرفت. زخم‌ها در روزهای 7 و 14 نمونه‌برداری و بررسی هیستوپاتولوژیک شد. داده‌ها با استفاده از نرم‌افزار SPSS و انجام آزمون ANOVA (Analysis of variance) تجزیه و تحلیل شد.یافته‌ها: بهبود زخم در گروه هیدروژل در مقایسه با دو گروه‌ دیگر به صورت معنی‌داری (05/0 > P) سریع‌تر و طول مدت ماندگاری اثر زخم و تغییر رنگ پوست در گروه هیدروژل نسبت به دو گروه دیگر به صورت معنی‌داری (05/0 > P) کمتر بود.نتیجه‌گیری: نتایج این پژوهش نشان داد که هیدروژل باعث تسریع در فرآیند ترمیم زخم می‌شود. 

کلیدواژه‌ها

عنوان مقاله [English]

The Effects of Polyvinyl Pyrrolidone Hydrogel Dressing on Open-Wound Healing in Rats

نویسندگان [English]

  • Reza Fazeli-Varzaneh 1
  • Seied Jamal Moshtaghian 2
  • Ardeshir Talebi 3
  • Fereidoon Abedini 4
1 MSc Student, Department of Biology, School of Sciences, University of Isfahan, Isfahan, Iran
2 Assistant Professor, Department of Biology, School of Sciences, University of Isfahan, Isfahan, Iran
3 Associate Professor, Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
4 Burn Causalities Hospital of Isfahan, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده [English]

Background: Different compounds and methods have been used for wound healing over years. New dressings such as hydrogels have shown remarkable effects on wound healing. Hydrogels have been considered as favorite wound dressings due to their transparency, exchange of respiratory gases, adsorption of water and exudates, regulation of wound temperature, prevention of infections and easy replacement. This study was designed to investigate the effects of polyvinylpyrrolidone hydrogel (PVP) dressing on wound healing in rats.Methods: 30 male Wistar rats weighing 230 ± 20 g were equally and semi-randomly distributed into 3 groups of control, treated with tetracycline and treated with hydrogel. After anesthesia and shaving the area, a 1 x 1 cm section was made on the skin of the back of the rats. The treatment period was 21 days and measurement of the wound area was performed on the days 0, 7, 10, 14, 17 and 21. Wound tissue samples for histopathologic examination were taken on the days 7 and 14. Data were analyzed via SPSS software using ANOVA test.Findings: Wound recovery in hydrogel group was significantly faster than other groups (P < 0.05). Duration of the wound presence and skin discoloration was also significantly shorter in hydrogel group (P < 0.05).Conclusion: The results of this study indicate that the hydrogel dressing leads to quick recovery of cutaneous wound. 

کلیدواژه‌ها [English]

  • Hydrogel dressing
  • Polyvinylpyrrolidone
  • Wound
  • Rat
  • Histopathology

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مجله دانشکده پزشکی اصفهان
دوره 32، شماره 313 - شماره پیاپی 313
بهمن و اسفند 1393
صفحه 2134-2148

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  • تاریخ دریافت: 08 آذر 1393
  • تاریخ بازنگری: 11 آبان 1403
  • تاریخ پذیرش: 17 فروردین 1401

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