تأثیر 8 ماه تمرین مقاومتی بر سطوح GH (Growth hormone)، 3IGFBP (3Insulin-like growth factor binding protein) و 1IGF (1Insulin-like growth factor) پلاسمای دو بیمار مبتلا به سوختگی شدید

نوع مقاله : مقاله های پژوهشی

نویسندگان

1 کارشناس ارشد، گروه فیزیولوژی ورزش، دانشکده‌ی تربیت بدنی و علوم ورزشی، دانشگاه اصفهان، اصفهان، ‌ایران

2 دانشیار، گروه فیزیولوژی ورزش، دانشکده‌ی تربیت بدنی و علوم ورزشی، دانشگاه اصفهان، اصفهان، ایران

3 استادیار، گروه فیزیولوژی ورزش، دانشکده‌ی تربیت بدنی و علوم تربیتی، دانشگاه اصفهان، اصفهان، ایران

4 استادیار، گروه روان‌شناسی کودکان با نیازهای خاص، دانشکده‌ی علوم تربیتی و روان‌شناسی، دانشگاه اصفهان، اصفهان، ایران

چکیده

مقدمه: افراد مبتلا به جراحت‌های حرارتی، افزایش کاتابولیسم پروتئین، تأخیر بهبود زخم، پاسخ ایمنی ضعیف و شیوع عفونت دارند. هدف از پژوهش حاضر بررسی اثر 8 ماه تمرین مقاومتی بر سطوح GH (Growth hormone)، 3IGFBP (3Insulin-like growth factor binding protein) و 1IGF (1Insulin-like growth factor) پلاسمای افراد مبتلا به سوختگی شدید بود.روش‌ها: روش پژوهشی از نوع مورد منفرد با طرح خط پایه‌ی چندگانه‌ی شرکت کنندگان بود. آزمودنی‌های این پژوهش دو زن با سوختگی شدید (درجه‌ی 3) در دامنه‌ی سنی 30-20 سال در بیمارستان سوانح سوختگی مرکزی شهر بودند، که پس از تعیین موقعیت خط پایه، به صورت پلکانی وارد طرح پژوهشی شدند. بیماران طی 8 ماه مداخله‌ی انفرادی، تمرین‌های مقاومتی انجام دادند و یک ماه پس از پایان مداخله، به مدت 2 ماه پی در پی تحت آزمون پیگیری قرار گرفتند. ابزار سنجش پژوهش حاضر نمونه‌گیری خونی، به منظور اندازه‌گیری GH، 1IGF و 3IGFBP بود. نمونه‌های خونی به صورت ناشتا و 24 ساعت پس از تمرین‌ها در پایان هر ماه گرفته شد.یافته‌ها: بر اساس شاخص‌های آمار توصیفی و تحلیل دیداری، تمرین‌های مقاومتی در هر دو آزمودنی موجب تغییر در سطوح 1IGF، GH و 3IGFBP شد. PND (Percentage of non-overlapping data) در GH 75 درصد برای آزمودنی اول و 5/87 درصد برای آزمودنی دوم و PND در 1IGF و 3IGFBP 100 درصد برای هر دو آزمودنی به دست آمد.نتیجه‌گیری: به نظر می‌رسد تمرین مقاومتی طولانی مدت بتواند باعث افزایش عوامل رشدی در افراد مبتلا به سوختگی شدید شود و یک محرک قوی برای سنتز پروتئین در این افراد باشد، یا از اثرات کاتابولیکی به وجود آمده پس از سوختگی و یا روند معکوس و کاهش بیش از حد این عوامل رشدی، پس از سوختگی جلوگیری کند و در نتیجه، باعث تسریع در بهبود جراحت‌ها شود.

کلیدواژه‌ها

عنوان مقاله [English]

The Effect of Eight Months of Resistive Training on Growth hormone, Insulin-Like Growth Factor1 and Insulin-like Growth Factor Binding Protein3 Plasma Levels in Patients with Severe Burns

نویسندگان [English]

  • Nasim Behzadnezhad 1
  • Sayyed Mohammad Marandi 2
  • Fahimeh Esfarjani 3
  • Ahmad Abedi 4
  • Fereshteh Bardia 1
1 Department of Exercise Physiology, School of Physical Education and Sport Science, University of Isfahan, Isfahan, Iran
2 Associate Professor, Department of Exercise Physiology, School of Physical Education and Sport Science, University of Isfahan, Isfahan, Iran
3 Assistant Professor, Department of Exercise Physiology, School of Physical Education and Sport Science, University of Isfahan, Isfahan, Iran
4 Assistant Professor, Department of Psychology of Exceptional Children, School of Education Sciences and Psychology, University of Isfahan, Isfahan, Iran
چکیده [English]

Background: The aim of this study was to investigate the effect of eight months of resistive training on growth hormone (GH), insulin-like growth factor1 (IGF1), and insulin-like growth factor binding protein3 (IGFBP3) plasma levels in patients with severe burns.Methods: The research method used in this study was of the individual-case type with multiple base lines for the participants. The examinees of this study included two women with severe burns (third degree) in the age range of 20 to 30 years confined in the Central Accidents and Burns Hospital, Isfahan, Iran. After determining the base-line position, the participants were entered into the project in a ladder step-by-step format. During the 8 months of individual intervention, they did the resistive training and one month after the finishing of the intervention period, they were put under follow-up examinations for 2 months. The measuring tool for this study was the blood tests taken for measuring GH, IGF1, and IGFBP3 plasma levels, which were taken at the fasting morning time and 24 hours after the exercises at the end of each month.Findings: Based on the visual analysis and descriptive statistical indexes, the resistive training in both examinees had caused a significant change in the GH, IGF1 and IGFBP3 plasma levels; as the percentage of non-overlapping data (PND) was 75% for the first and 87.5% for the second examinee in GH level, and 100% for both examinees in IGF1 and IGFBBP3 levels.Conclusion: It seems that long-term resistive training can cause elevation of the plasma level of some growth factors in patients with severe burns or it can prevent the reverse process and intense decline in these factors after the burn takes place. In addition, it would make these patients become free of the need for frequent surgeries and using different equipments.

کلیدواژه‌ها [English]

  • Burn
  • Growth hormone (GH)
  • Insulin-like growth factor1 (IGF1)
  • Insulin-like growth factor binding protein3 (IGFBP3)
  • Resistive exercise
  • Single subject research

مراجع

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مجله دانشکده پزشکی اصفهان
دوره 32، شماره 279 - شماره پیاپی 279
فروردین و اردیبهشت 1393
صفحه 388-407

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سابقه مقاله

  • تاریخ دریافت: 15 مرداد 1392
  • تاریخ بازنگری: 11 آبان 1403
  • تاریخ پذیرش: 17 فروردین 1401

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