Influence of Radiation Therapy Parameters on the Quality of Life in Patients with Head and Neck Cancer Treated with Three-Dimensional Conformal Radiotherapy

Document Type : Original Article (s)

Authors

1 MSc Student, Department of Medical Physics and Imaging, Urmia University of Medical Sciences, Urmia, Iran

2 Associate Professor, Department of Medical Physics and Imaging, Urmia University of Medical Sciences, Urmia, Iran

Abstract

Background: The present study aimed to investigate the influence of therapeutic parameters of radiation therapy on the quality life in patients suffering from head and neck cancer after being treated with three-dimensional conformal radiotherapy (3D-CRT).Methods: In this study, the quality life of 45 patients with organs at risks of thyroid, salivary glands and eyes was assessed after treatment of three-dimensional conformal radiotherapy under the influence of parameters such as the treatment region, prescribed dose, the grade of cancer and the type of treatment. The European organization for research and treatment of cancer quality of life questionnaire-core 30 (EORTC QLQ-C30) and the Quality of life questionnaire-head and neck 35 (QLQ–H&N35) were used to assess the quality of life in patients with head and neck cancer. Having collected data, Mann-Whitney and Kruskal-Wallis tests were used to analyze. The level of significance was considered as 0.05 in all the tests.Findings: There was a significant correlation between the site of the tumors in different regions of head and neck and the reduction in quality life due to thyroid dysfunction (P = 0.002). However, there was not any significant correlation between the quality life and total received dose, the grade of cancer, and the type of treatment.Conclusion: According to the results of this study and other researches, three-dimensional conformal radiotherapy with protection of organs at risk lead to satisfactory maintenance of normal tissues of head and neck regions after the treatment. This reveals the importance of using new techniques and methods to reduce the probability of normal tissue side effects and finally improve the quality life of the patients after taking the course of treatment.  

Keywords

References

  1. van de Water TA, Bijl HP, Schilstra C, Pijls-Johannesma M, Langendijk JA. The potential benefit of radiotherapy with protons in head and neck cancer with respect to normal tissue sparing: a systematic review of literature. Oncologist 2011; 16(3): 366-77.
  2. Taylor LS. History of the International Commission on Radiological Units and Measurements (ICRU). Health Phys 1958; 1(3): 306-14.
  3. International Commission on Radiation Units and Measurements (ICRU).
  4. Jackson A, Kutcher GJ, Yorke ED. Probability of radiation-induced complications for normal tissues with parallel architecture subject to non-uniform irradiation. Med Phys 1993; 20(3): 613-25.
  5. Drzymala RE, Mohan R, Brewster L, Chu J, Goitein M, Harms W, et al. Dose-volume histograms. Int J Radiat Oncol Biol Phys 1991; 21(1): 71-8.
  6. Fertil B, Malaise EP. Inherent cellular radiosensitivity as a basic concept for human tumor radiotherapy. Int J Radiat Oncol Biol Phys 1981; 7(5): 621-9.
  7. Dehkordi A, Heydarnejad MS, Fatehi D. Quality of Life in cancer patients undergoing Chemotherapy. Oman Med J 2009; 24(3): 204-7.
  8. Bjordal K, de Geraeff A, Fayers PM, Hammerlid E, van Pottelsberghe C, Curran D, et al. A 12 country field study of the EORTC QLQ-C30 (version 3.0) and the head and neck cancer specific module (EORTC QLQ-H&N35) in head and neck patients. EORTC Quality of Life Group. Eur J Cancer 2000; 36(14): 1796-807.
  9. Zmijewska-Tomczak M, Milecki P, Olek-Hrab K, Hojan K, Golusinski W, Rucinska A, et al. Factors influencing quality of life in patients during radiotherapy for head and neck cancer. Arch Med Sci 2014; 10(6): 1153-9.
  10. Hassan SJ, Weymuller EA, Jr. Assessment of quality of life in head and neck cancer patients. Head Neck 1993; 15(6): 485-96.
  11. Hey J, Setz J, Gerlach R, Janich M, Hildebrandt G, Vordermark D, et al. Parotid gland-recovery after radiotherapy in the head and neck region--36 months follow-up of a prospective clinical study. Radiat Oncol 2011; 6: 125.
  12. Braam PM, Roesink JM, Raaijmakers CP, Busschers WB, Terhaard CH. Quality of life and salivary output in patients with head-and-neck cancer five years after radiotherapy. Radiat Oncol 2007; 2: 3.
  13. Zhao N, Yang R, Jiang Y, Tian S, Guo F, Wang J. A hybrid IMRT/VMAT technique for the treatment of nasopharyngeal cancer. Biomed Res Int 2015; 2015: 940102.
  14. Chatterjee S, Willis N, Locks SM, Mott JH, Kelly CG. Dosimetric and radiobiological comparison of helical tomotherapy, forward-planned intensity-modulated radiotherapy and two-phase conformal plans for radical radiotherapy treatment of head and neck squamous cell carcinomas. Br J Radiol 2011; 84(1008): 1083-90.
  15. Castelli J, Simon A, Louvel G, Henry O, Chajon E, Nassef M, et al. Impact of head and neck cancer adaptive radiotherapy to spare the parotid glands and decrease the risk of xerostomia. Radiat Oncol 2015; 10(1): 6.
  16. Otto K. Volumetric modulated arc therapy: IMRT in a single gantry arc. Med Phys 2008; 35(1): 310-7.
  17. Lee TF, Ting HM, Chao PJ, Fang FM. Dual arc volumetric-modulated arc radiotherapy (VMAT) of nasopharyngeal carcinomas: a simultaneous integrated boost treatment plan comparison with intensity-modulated radiotherapies and single arc VMAT. Clin Oncol (R Coll Radiol) 2012; 24(3): 196-207.
  18. Sheng K, Dong P, Gautam A, Cheng CW, Ruan D, Low D, et al. Evolution of ipsilateral head and neck radiotherapy. Curr Cancer Ther Rev 2014; 10(4): 343-52.
  19. Vernat SS, Ali D, Messina C, Pommier P, Dussart S, Puyraveau M, et al. Intensity modulated arc therapy in bilaterally irradiated head and neck cancer: a comparative and prospective multicenter planning study. Cancer Invest 2014; 32(5): 159-67.
  20. Shilkrut M, Belkacemi Y, Kuten A. Secondary malignancies in survivors of breast cancer: how to overcome the risk. Crit Rev Oncol Hematol 2012; 84(Suppl 1): e86-e89.
  21. Wang W, Lang J. Strategies to optimize radiotherapy based on biological responses of tumor and normal tissue. Exp Ther Med 2012; 4(2): 175-80.
Journal of Isfahan Medical School
Volume 33, Issue 365 - Serial Number 365
November and December 2016
Pages 2302-2308

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History

  • Receive Date: 02 October 2015
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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