Effects of 12 Weeks of Endurance Training on Soluble Intercellular Adhesion Molecule-1 (sICAM-1) (Cardiovascular Inflammation Factor) and Lipid Profiles of Elderly Men

Document Type : Original Article (s)

Authors

1 Department of Physical Education, School of Physical Education and Sport Sciences, Islamic Azad University, Fars Sciencs and Research Branch, Shiraz, Iran

2 Associate Professor, Department of Physical Education, School of Physical Education and Sport Sciences, University of Sistan and Baluchestan, zahedan, Iran

3 Assistant Professor, Department of Physical Education, School of Physical Education and Sport Sciences, Islamic Azad University, Fars Sciences and Research Branch, Shiraz, Iran

Abstract

Background: Soluble intercellular adhesion molecule-1 (sICAM-1) has been identified as a biomarker of cardiovascular diseases and atherosclerosis. The purpose of this study was to examine the effects of 12 weeks of endurance training on sICAM-1, as a cardiovascular inflammation factor, and lipid profiles of elderly men.Methods: Among elderly men who volunteered to participate in this study, 24 persons were randomly selected and divided into two groups of control (n = 12) and intervention (n = 12). Training was performed 3 sessions a week for 12 weeks. The time and intensity (50-75% of maximum heart rate) of exercises were fixed. Blood sampling was conducted after 14 hours of fasting and 24 hours after the last session of training both in similar conditions. The commercial kit of Diaclone (France) was used for biochemical analysis and evaluation of sICAM-1 values. In order to evaluate lipid profiles, an enzyme-linked immunosorbent assay (ELISA) reader (Hyperion, Pars Azmoon Co., Iran) was used. The resulting data was analyzed in SPSS15 using Kolmogorov-Smirnov, paired-t, and student's-t tests at a significance level of α ≤ 0.05.Findings: The results of this study revealed that 12 weeks of endurance training significantly reduced sICAM-1 values (P ≤ 0.05) as a new biomarker for the prediction of cardiovascular accidents. However, no significant reduction (P ≥ 0.05) was observed in lipid profile values (total cholesterol, triglyceride, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol) of elderly men.Conclusion: By noticing significant reductions in inflammatory biomarker of sICAM-1, despite the absence of significant reductions in lipid profile values, caused by endurance training, perhaps sICAM-1 biomarker can be introduced as a more sensitive and accurate marker for the prediction of cardiovascular diseases.

Keywords

References

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Journal of Isfahan Medical School
Volume 29, Issue 155 - Serial Number 155
September and October 2011
Pages 1426-1434

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History

  • Receive Date: 30 November 2011
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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