بررسی اثر بهبود دهنده‌ی عصاره‌ی چای سبز بر سمیت کلیوی

نوع مقاله : مقاله های پژوهشی

نویسندگان

1 استاد، گروه داخلی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

2 پژوهشگر، انستیتو پژوهشی نیکان، اصفهان، ایران

3 استادیار، گروه اپیدمیولوژی و آمار ریستی، دانشکده‌ی بهداشت، دانشگاه علوم پزشکی شهرکرد، شهرکرد، ایران

4 پژوهشگر، مرکز تحقیقات گیاهان دارویی، دانشگاه علوم پزشکی شهرکرد، شهرکرد، ایران

5 استاد، مرکز تحقیقات گیاهان دارویی، دانشگاه علوم پزشکی شهرکرد، شهرکرد، ایران

چکیده

مقدمه: آسیب کلیوی ناشی از تزریق ماده‌ی حاجب، می‌تواند منجر به نقص عملکردی کلیه شود. به همین دلیل، به تازگی، توجه زیادی به سمت کاربرد گیاهان دارویی در پیش‌گیری و درمان بیماری‌های مختلف به خصوص عوارض کلیوی و کبدی آن‌ها معطوف شده است. بیشترین تأثیرات مفید این گیاهان دارویی، به دلیل وجود ویژگی‌های آنتی‌اکسیدانی آن‌ها می‌باشد که در این میان، چای سبز به دلیل دارا بودن خواص آنتی‌اکسیدانی فراوان بسیار مورد توجه قرار گرفته است.روش‌ها: این مطالعه، بر روی 40 رت انجام شد که به طور تصادفی به چهار گروه شاهد، ماده‌ی حاجب، ماده‌ی حاجب و چای سبز و ماده‌ی حاجب با پیش درمانی با چای سبز تقسیم شدند. در نهایت، پس از خون‌گیری سطح کراتینین و نیتروژن اوره‌ی خون در آن‌ها اندازه‌گیری شد. داده‌ها با استفاده از آزمون آماری ANOVA و نرم‌افزار SPSS واکاوی گردید. 050/0 > P به عنوان سطح معنی‌داری در نظر گرفته شد.یافته‌ها: در گروه دریافت کننده‌ی ماده‌ی حاجب، سطح کراتینین خون به طور معنی‌داری بیش از سایر گروه‌ها بود (001/0 = P). همچنین، سطح کراتینین در دو گروه تجربی دیگر در مقایسه‌ی با گروه دوم کاهش معنی‌داری را نشان داد.نتیجه‌گیری: پلی‌فنول‌ موجود در چای سبز، سهم مفیدی بر عوارض ناشی از استرس اکسیداتیو دارد و می‌تواند اثر پیش‌گیری کننده بر میزان کراتینین خون داشته باشد.

کلیدواژه‌ها

عنوان مقاله [English]

Improving Effects of Green Tea on Renal Nephrotoxicity (A Biochemical Study)

نویسندگان [English]

  • Hamid Nasri 1
  • Samaneh Khodadadi 2
  • Mitra Moradi 2
  • Ali Ahmadi 3
  • Golnoosh Kohi 4
  • Mahmoud Rafieian-Kopaei 5
1 Professor, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Researcher, Nickan Research Institute, Isfahan, Iran
3 Assistant Professor, Department of Epidemiology and Biostatistics, School of Public Health, Shahrekord University of Medical Sciences, Shahrekord, Iran
4 Researcher, Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
5 Professor, Medical Plants Research Center, Shahrekord University of Medical Sciences, Sharekord, Iran
چکیده [English]

Background: Contrast media-induced acute renal damage could lead to renal failure; so, recently much attention has been made on the efficacy of medicinal plants in prevention and treatment of various diseases, especially in kidney and liver complications.Methods: Forty rats were randomly divided into four groups of 10 consisting of control, contrast media, contrast media plus green tea and green tea pretreatment and contrast media group, respectively. After collecting blood samples from lateral tail vein blood urea nitrogen (BUN) and serum creatinine were measured for assessing tubular nephrotoxicity.Findings: In the second group creatinine level was significantly higher than other groups (P < 0.05).Conclusion: Green tea can provide an applicable intervention approach in individuals with a risk for contrast induced acute kidney injury. So, further preclinical investigations are necessary to confirm the efficiency of this herb against various injurious substances to the renal tubular cells.

کلیدواژه‌ها [English]

  • Green Tea
  • Contrast Media
  • Medicinal Plants
  • Acute Kidney Injury
  • Toxicity

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مجله دانشکده پزشکی اصفهان
دوره 34، شماره 385 - شماره پیاپی 385
مرداد و شهریور 1395
صفحه 642-648

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  • تاریخ دریافت: 18 آبان 1394
  • تاریخ بازنگری: 11 آبان 1403
  • تاریخ پذیرش: 17 فروردین 1401

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