مروری بر انواع ایمونوتوکسین در درمان سرطان پروستات

نوع مقاله : مقاله مروری

نویسندگان

1 گروه زیست‌فن‌آوری پزشکی، دانشکده‌ی پیراپزشکی، دانشگاه علوم پزشکی ایران، تهران، ایران

2 استادیار، گروه علوم آزمایشگاهی، دانشکده‌ی پیراپزشکی، دانشگاه علوم پزشکی ایران، تهران، ایران

3 استاد، گروه زیست فن‌آوری پزشکی، دانشکده‌ی پیراپزشکی، دانشگاه علوم پزشکی ایران، تهران، ایران

چکیده

سرطان پروستات، دومین سرطان شایع و پنجمین علت مرگ و میر سرطان در مردان است. بسیاری از بیماران مبتلا به سرطان پروستات پیشرفته، به علت فقدان درمان مؤثر فوت می‌کنند. بنابراین، راهبردهای جدید درمانی مورد نیاز است. با توجه به بیان موضعی آنتی‌ژن‌های سرطان پروستات، این احتمال وجود دارد که اندازه‌گیری میزان آن‌ها در بافت‌های سرطانی، باعث معرفی نشانگرهای جدید برای تشخیص، پیش‌آگهی و همچنین، درمان سرطان پروستات می‌شود. بنابراین، ایمنی‌درمانی خاص علیه آن‌ها ممکن است یک روش درمان جدید برای بهبود مدیریت سرطان پروستات باشد. ایمونوتوکسین‌درمانی، روش جدیدی در درمان هدفمند سرطان است که در آن، آنتی‌بادی به توکسین کانژوگه شده است. ایمونوتوکسین‌ها، به علت ویژگی آنتی‌بادی به طور انتخابی علیه سلول هدف عمل می‌کنند و سبب کشتن سلول‌ها از طریق توکسین باکتری یا گیاهی می‌شوند. بنابراین، ایمونوتوکسین یک داروی امیدوار کننده در زمینه‌ی درمان در بیماران مبتلا به سرطان پروستات است. با توجه به اهمیت ایمونوتوکسین‌ها در درمان بیماران مبتلا به سرطان پروستات، هدف از انجام این مطالعه، جمع‌بندی یافته‌های مطالعات پیش بالینی در ارتباط با انواع ایمونوتوکسین‌های به کار رفته در این بیماری و در نهایت، پیشنهادهای ارایه شده برای درمان هر چه بهتر سرطان پروستات در آینده می‌باشد.

کلیدواژه‌ها

عنوان مقاله [English]

A Review on the Role of the Different Types of Immunotoxins in the Treatment of Prostate Cancer

نویسندگان [English]

  • Milad Chizari 1
  • Monireh Mohsenzadegan 2
  • Mohammad Morad Farajollahi 3
1 Department of Medical Biotechnology, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran
2 Assistant Professor, Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran
3 Professor, Department of Medical Biotechnology, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran
چکیده [English]

Prostate cancer is the second most frequent cancer and the fifth leading cause of cancer death in men. Many patients with metastatic prostate cancer die due to lack of effective treatment. Therefore, new therapeutic strategies are needed. Due to the local expression of prostate cancer antigens, evaluation of their existence in cancerous tissues would probably result in introducing new biomarkers for diagnosis and prognosis, as well as treatment of prostate cancer. Hence, specific immunotherapy against the new biomarkers may be a new way to treat and improve the management of prostate cancer. Immunotoxin therapies are novel targeted cancer therapies in which a toxin is a fusion of a monoclonal antibody. Immunotoxins selectively operate against the target cell due to the specific antibody, and kill cells through bacterial or plant toxin. So, immunotoxin is a promising candidate for therapeutic applications in patients with prostate cancer. Considering the importance of immunotoxins in the treatment of patients with prostate cancer, the purpose of this study was to review various immunotoxins used in prostate cancer in previous preclinical studies and finally, we made suggestions for the advancement of future studies.

کلیدواژه‌ها [English]

  • Prostate cancer
  • Immunotherapy
  • Immunotoxin
  • Monoclonal antibodies

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مجله دانشکده پزشکی اصفهان
دوره 37، شماره 530 - شماره پیاپی 530
مرداد و شهریور 1398
صفحه 655-666

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  • تاریخ دریافت: 29 خرداد 1398
  • تاریخ بازنگری: 11 آبان 1403
  • تاریخ پذیرش: 17 فروردین 1401

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