The Comparison of Serum Zinc Level in Behcet Patients and Healthy Controls

Document Type : Original Article(s)

Authors

1 Assistant Professor of Rheumatology, School of Medicine, Kashan University of Medical Sciences, Kashan

2 Associated Professor of Rheumatology, Rheumatology Research Center, Tehran University of Medical Sciences, Tehran

3 Professor of Rheumatology, Rheumatology Research Center, Tehran University of Medical Sciences, Tehran

4 Assistant Professor of Infectious Disease, School of Medicine, Kashan University of Medical Sciences, Kashan

5 Researcher, Rheumatology Research Center, Tehran University of Medical Sciences, Tehran

6 Assistant Professor of Rheumatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan

Abstract

Background:
Zinc was suggested as an antioxidant and immunomodulator trace element in parallel with other trace elements and antioxidant enzymes. Recently selenium deficiency was indicated in Behcet disease. In this study, we evaluated the correlation of serum zinc level and Behcet disease.
Methods:
In a cross-sectional, descriptive study serum level of zinc was measured in 49 cases satisfying International Study Group criteria and 51 controls. Serum zinc level was measured by atomic absorption spectrometry and compared the mean of Findings:
serum selenium levels in both case and control and was analyzed by T-test statistical test.
Serum zinc level (mean±SD) in patients (66.4±15.38) were significantly (p<0.0005) lower than healthy controls (86.87±17.18). When considering Global Physician Assessment, there was not significantly difference between active (67.47±14.3) and non-active (69.53±13.65) patients. A significant decrease in Zinc level was present in ocular involved patients. (p <0.001).
Conclusion:
Our results showed that serum zinc level is lower in patients than healthy control group. It is not clear that zinc is a predicting factor of exacerbation or activity of disease. More studies are needed for understanding the precise relationship between zinc and Behcet etiopathology.
Key words:Behcet disease, zinc.
Journal of Isfahan Medical School
Volume 27, Issue 95 - Serial Number 95
March and April 2009
Pages 217-222

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History

  • Receive Date: 07 November 2010
  • Revise Date: 26 May 2024
  • Accept Date: 06 April 2022

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