Salsalate Efficacy on Treatment of Fatty Liver in Diabetes; Clinical Trial in Diabetic and Prediabetic Patients

Document Type : Original Article(s)

Authors

1 Endocrinologist, Endocrinology and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

2 Professor, Endocrinology and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

3 Associate Professor, Department of Radiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

4 Resident, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

5 Associate Professor, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Nearly two-third of patients with type II diabetes have degrees of fatty liver; this may induce some side effects in them. This study aimed to find effect of salsalate on treatment of steatohepatitis and correlation of fatty liver with metabolic syndrome in the setting of impaired glucose metabolism.Methods: In a double-blind randomized trial within two distinct groups i.e. recently diagnosed diabetics and prediabetic cases allocated in two arms of the intervention to receive 3 g salsalate or placebo. All cases underwent glucose and lipid level studies and liver ultrasound study.Finding: Within 46 patients with diabetes, 34 (74%) had fatty liver in ultrasound; this ratio was 75 percent in 113 prediabetic cases. Relative frequency of fatty liver stages did not differ between diabetics and prediabetics. Within diabetics, mean AST level of fatty liver cases (23 ± 7 IU/dl) was higher than others (18 ± 3 IU/dl) (P < 0.05). Changes in transaminase levels following intervention did not significantly differ, comparing drug and placebo arms in two subgroups.Conclusion: According to the findings, if diabetes could be assumed as the logical consequence of prediabetic state, it seems that fatty liver did develop before this preliminary status. In this study, salsalate could not change biochemical markers of fatty liver significantly.

Keywords

References

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Journal of Isfahan Medical School
Volume 28, Issue 116 - Serial Number 116
September and October 2011
Pages 1024-1031

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History

  • Receive Date: 29 January 2011
  • Revise Date: 24 May 2024
  • Accept Date: 06 April 2022

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