Effects of 12 Weeks Aerobic Training on Body Composition, Serum Homocysteine and CRP Levels in Obese Women

Document Type : Original Article (s)

Authors

1 Assistant Professor, Department of Exercise Physiology, School of Physical Education and Sport Sciences, Khorasgan Branch, Islamic Azad University, Isfahan, Iran

2 Associate Professor, Department of Exercise Physiology, School of Physical Education and Sport Sciences, The University of Isfahan, Isfahan, Iran

3 Professor, Department of Pediatrics, School of Medicine, Child Health Promotion Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Epidemiological studies indicate that elevated serum levels of homocysteine and C-reactive protein (CRP) is independently associated with risk of cardiovascular disease. The aim of this study was to determine the effects of 12 weeks aerobic training on levels of serum homocysteine and CRP levels in obese women.Methods: 20 healthy obese female students with similar age and weight were randomly devided in intervention and control groups. The intervention group was trained in an aerobic exercise program for 12 weeks (3 sessions weekly). This program was a treadmill exercise with 50-65 percent maximum heart rate intensity for 30-45 minutes in each session. Weight, body fat percentage, body mass index and waist to hip ratio were measured in the beginning and the end of the study for all of the subjects by using the analysis of body composition. In addition homocysteine and CRP levels in the fasting state were evaluated with ELISA (enzyme–linked immunosorbent assay) method before and after the exercise program. Data were analyzed by the Paired t-test and covariance analysis test.Findings: The mean age in both groups were 25 ± 5 years. The results showed a significant decrease in weight, fat percentage, body mass index, waist to hip ratio parameters and homocysteine and CRP levels in exercise group after 12 week exercise period. At the end of the study we found statistically significant differences in weight, fat percentage, body mass index, waist hip ratio parameters and homocysteine and CRP levels between 2 groups. Conclusion: According to our result, a 12 week regular aerobic exercise program, with moderate-intensity play an important role in weight control in obese individual and decrease their cardiovascular disease risk factors.

Keywords

References

  1. Santosa S, Demonty I, Lichtenstein AH, Cianflone K, Jones PJ. An investigation of hormone and lipid associations after weight loss in women. J Am Coll Nutr 2007; 26(3): 250-8.
  2. Tremblay A. Physical activity and obesity. Baillieres Best Pract Res Clin Endocrinol Metab 1999; 13(1): 121-9.
  3. Cai BZ, Gong DM, Liu Y, Pan ZW, Xu CQ, Bai YL, et al. Homocysteine inhibits potassium channels in human atrial myocytes. Clin Exp Pharmacol Physiol 2007; 34(9): 851-5.
  4. Joubert LM, Manore MM. Exercise, nutrition, and homocysteine. Int J Sport Nutr Exerc Metab 2006; 16(4): 341-61.
  5. Sütken E, Akalin A, Ozdemir F, Colak O. Lipid profile and levels of homocysteine, leptin, fibrinogen and C-reactive protein in hyperthyroid patients before and after treatment. Dicle Medical Journal 2010; 37(1): 1-7.
  6. Di SM, Banfi G, Stel G, Cauci S. Association of recreational physical activity with homocysteine, folate and lipid markers in young women. Eur J Appl Physiol 2009; 105(1): 111-8.
  7. Selvin E, Paynter NP, Erlinger TP. The effect of weight loss on C-reactive protein: a systematic review. Arch Intern Med 2007; 167(1): 31-9.
  8. Kelley GA, elley KS. Effects of Exercise and Physical Activity on Homocysteine in Adults: A Meta-Analysis of Randomized Controlled Trials. JEP 2008; 11(5): 12-23.
  9. Clarkson PM. Micronutrients and exercise: anti-oxidants and minerals. J Sports Sci 1995; 13(Spec No): S11-S24.
  10. Freeman DJ, Norrie J, Caslake MJ, Gaw A, Ford I, Lowe GD, et al. C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study. Diabetes 2002; 51(5): 1596-600.
  11. Albert CM, Ma J, Rifai N, Stampfer MJ, Ridker PM. Prospective study of C-reactive protein, homocysteine, and plasma lipid levels as predictors of sudden cardiac death. Circulation 2002; 105(22): 2595-9.
  12. Kim K, Valentine RJ, Shin Y, Gong K. Associations of visceral adiposity and exercise participation with C-reactive protein, insulin resistance, and endothelial dysfunction in Korean healthy adults. Metabolism 2008; 57(9): 1181-9.
  13. Roh EJ, Lim JW, Ko KO, Cheon EJ. A useful predictor of early atherosclerosis in obese children: serum high-sensitivity C-reactive protein. J Korean Med Sci 2007; 22(2): 192-7.
  14. Nicklas BJ, Hsu FC, Brinkley TJ, Church T, Goodpaster BH, Kritchevsky SB, et al. Exercise training and plasma C-reactive protein and interleukin-6 in elderly people. J Am Geriatr Soc 2008; 56(11): 2045-52.
  15. Cosio-Lima LM, Schuler PB, Reynolds KL, Taylor L, Kellog G, Cerney J, et al. The effects of age and type-2 diabetes on the release of interleukin (IL)-6, IL-10,TNF-alpha, and cortisol in response to acute exercise. JEP 2008; 11(3): 33-41.
  16. Petersen MW, Pedersen BK. The anti-inflammatory effect of exercise. Journal of Applied Physiology 2005; 98(1): 1154-62.
  17. Randeva HS, Lewandowski KC, Drzewoski J, Brooke-Wavell K, O'Callaghan C, Czupryniak L, et al. Exercise decreases plasma total homocysteine in overweight young women with polycystic ovary syndrome. J Clin Endocrinol Metab 2002; 87(10): 4496-501.
  18. Vincent HK, Bourguignon C, Vincent KR. Resistance training lowers exercise-induced oxidative stress and homocysteine levels in overweight and obese older adults. Obesity (Silver Spring) 2006; 14(11): 1921-30.
  19. Torjman MC, Zafeiridis A, Paolone AM, Wilkerson C, Considine RV. Serum leptin during recovery following maximal incremental and prolonged exercise. Int J Sports Med 1999; 20(7): 444-50.
  20. Taghian F, Nik Bakht H, Karbasian A. Effect of aerobic training on plasma leptin levels in obese women. Research on Sport Sciences 2006; 4(11): 45-58.
  21. Harris RA, Padilla J, Hanlon KP, Rink LD, Wallace JP. The flow-mediated dilation response to acute exercise in overweight active and inactive men. Obesity (Silver Spring) 2008; 16(3): 578-84.
  22. Kang HS, Lee MC, You YC, Chang N. Effect of Endurance Training on the Plasma Homocysteine and B Vitamin Levels in Male Adolescent Field Hockey Players. Korean J Nutr 2007; 37(10): 881-7.
  23. Gelecek N, Teoman N, Ozdirenc M, Pinar L, Akan P, Bediz C, et al. Influences of acute and chronic aerobic exercise on the plasma homocysteine level. Ann Nutr Metab 2007; 51(1): 53-8.
  24. Namazi A, Agha Alinejad H, Piry M, Rahbarizadeh F. Effect of short long circles resistance training on serum levels of homocysteine and CRP in active and inactive women. Journal of Endocrinology and Metabolism 2010; 12(2): 169-76.
  25. Meyer AA, Kundt G, Lenschow U, Schuff-Werner P, Kienast W. Improvement of early vascular changes and cardiovascular risk factors in obese children after a six-month exercise program. J Am Coll Cardiol 2006; 48(9): 1865-70.
  26. Borrione P, Rizzo M, Spaccamiglio A, Salvo RA, Dovio A, Termine A, et al. Sport-related hyperhomocysteinaemia: a putative marker of muscular demand to be noted for cardiovascular risk. Br J Sports Med 2008; 42(11): 894-900.
  27. Stewart LK, Flynn MG, Campbell WW, Craig BA, Robinson JP, Timmerman KL, et al. The influence of exercise training on inflammatory cytokines and C-reactive protein. Med Sci Sports Exerc 2007; 39(10): 1714-9.
  28. Hamedinia MR, Haghighi AH, Ravasi A. The effect of aerobic training on inflammatory factors. of heart disease in obese men. Iranian Journal of Harkat 2007; 34: 47-58.
  29. Weight LM, Alexander D, Jacobs P. Strenuous exercise: analogous to the acute-phase response? Clin Sci (Lond) 1991; 81(5): 677-83.
  30. Liesen H, Dufaux B, Hollmann W. Modifications of serum glycoproteins the days following a prolonged physical exercise and the influence of physical training. Eur J Appl Physiol Occup Physiol 1977; 37(4): 243-54.
  31. Kasapis C, Thompson PD. The effects of physical activity on serum C-reactive protein and inflammatory markers: a systematic review. J Am Coll Cardiol 2005; 45(10): 1563-9.
Journal of Isfahan Medical School
Volume 29, Issue 149 - Serial Number 149
July and August 2011
Pages 1037-1045

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History

  • Receive Date: 01 September 2011
  • Revise Date: 26 May 2024
  • Accept Date: 06 April 2022

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