P-گلیکوپروتئین 170؛ اهمیت بالینی و عملکرد پاتوفیزیولوژیک آن در سرطان

نوع مقاله : مقاله مروری

نویسندگان

1 کارشناس ارشد، گروه زیست شناسی، دانشکده‌ی علوم، دانشگاه اصفهان، اصفهان، ایران

2 استادیار، گروه زیست شناسی، دانشکده‌ی علوم، دانشگاه اصفهان، اصفهان، ایران

چکیده

مقدمه: P- گلیکوپروتئین 170 توسط ژن MDR1 کد می‌شود و به خانواده‌ی انتقال دهنده‌ها‌ی ATP binding cassette (ABC) تعلق دارد. این پروتئین اعمال مهمی را در فیزیولوژی سلولی بر عهده داشته، عملکرد آن در سلول‌های سرطانی منجر به شکست درمان می‌گردد. در این مطالعه، ساختار P- گلیکوپروتئین و ژن آن معرفی شده است. علاوه بر این، نقش پاتوفیزیولوژیک این پروتئین و تأثیر آن بر فارماکوکینتیک مورد بحث قرار گرفته است.روش‌ها: به منظور معرفی جدیدترین مطالعات در رابطه با P- گلیکوپروتئین، MDR1 و اهمیت بالینی آن‌ها در سلامتی و بیماری، پایگاه‌های داده‌ی EBSCO، Elsevier، PubMed و OVID مورد بررسی قرار گرفت. همچنین، به بحث یافته‌های اخیر نویسندگان در زمینه‌ی MDR1 و لوسمی پرداخته شده است.یافته‌ها: P- گلیکوپروتئین به طور طبیعی در بسیاری از بافت‌ها شامل کبد، روده و مغز بیان می‌شود. این پروتئین در بسیاری از فرایندهای سلولی از قبیل التهاب، تمایز سلول‌های ایمنی، سمیت‌زدایی و ترشح هورمون‌ها نقش دارد. کاهش کارایی درمان و عود بیماری متعاقب آن به علت مقاومت دارویی مهم‌ترین پیامد عملکرد این پروتئین بوده است و به عنوان یکی از پر چالش‌ترین موانع در درمان سرطان مورد توجه می‌باشد.نتیجه‌گیری: P- گلیکوپروتئین یک انتقال دهنده‌ی مهم با نقش حفاظتی در حیات سلول طبیعی است. از طرفی، در برخی سلول‌های سرطانی می‌تواند عامل مقاومت دارویی باشد. مطالعات جامع در رابطه با MDR1 و P- گلیکوپروتئین 170 می‌تواند روش‌های جدید تشخیصی و درمانی را فراهم نماید.

کلیدواژه‌ها

عنوان مقاله [English]

P-Glycoprotein 170; Its Clinical Importance and Pathophysiological Role in Cancer

نویسندگان [English]

  • Marjan Abedi 1
  • Soheila Rahgozar 2
1 Department of Biology, School of Science, University of Isfahan, Isfahan, Iran
2 Assistant Professor, Department of Biology, School of Science, University of Isfahan, Isfahan, Iran
چکیده [English]

Background: P-glycoprotein 170 is encoded by MDR1 gene and belongs to the ATP-binding cassette transporters (ABC) superfamily. This protein has important roles in cell physiology and its function in cancerous cells may contribute to failure treatment. The molecular structure of P-glycoprotein and its corresponding gene is introduced in this research. Moreover, the pathophysiological role of this protein and its effects on pharmacokinetics are discussed.Methods: EBSCO, Elsevier, PubMed and OVID databases were reviewed to introduce the most recent studies regarding p-glycoprotein, MDR1 and their clinical importance in health and disease. Authors’ novel findings regarding MDR1 and leukemia were also discussed.Findings: P-glycoprotein is naturally expressed in many tissues such as liver, intestine and brain. This protein is involved in many cellular processes such as inflammation, immune cell differentiation, detoxification and hormone secretion. Reduction of the treatment efficiency and the consecutive relapse due to drug resistance are the most important consequences of this protein function, and addressed as the most challenging obstacles in cancer treatment.Conclusion: P-glycoprotein is an important transporter with a protecting function in normal cell life. On the other hand, it may provide drug resistance in some cancerous cells. Comprehensive studies about MDR1 and P-glycoprotein 170 may provide novel approaches to new diagnostics and therapeutics.

کلیدواژه‌ها [English]

  • P-glycoprotein
  • MDR1
  • Drug resistance
  • Clinical importance

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مجله دانشکده پزشکی اصفهان
دوره 31، شماره 228 - شماره پیاپی 228
فروردین و اردیبهشت 1392
صفحه 274-293

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  • تاریخ دریافت: 03 دی 1391
  • تاریخ بازنگری: 24 اردیبهشت 1403
  • تاریخ پذیرش: 17 فروردین 1401

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