Ethambutol-Susceptibility of Clinical and Environmental Atypical Mycobacteria Isolated from Isfahan, Iran

Document Type : Original Article (s)

Authors

1 MSc Student, Department of Microbiology, School of Medicine AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran

2 Associate professor Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 Assistant Professor, Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

4 Assistant Professor, Nosocomial Infection Research Center AND Department of Microbiology, Isfahan University of Medical Sciences, Isfahan, Iran

5 Assistant Professor, Infectious Diseases and Tropical Medicine Research Center AND Department of Microbiology, Isfahan University of Medical Sciences, Isfahan, Iran

6 Assistant Professor, Department of Microbiology, School of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran

7 MSc Student, Department of Microbiology, Islamic Azad University, Fars Science and Research Branch, Shiraz, Iran

Abstract

Background: Due to increasing of AIDS and nontuberculous mycobacteria (NTM) pathogenesis in this group of patients, the role of NTM is becoming bold and more concerned. Furthermore, the treatment of NTM diseases is species related. Thus, information about the pattern of treatment to cure the related diseases is very important in any geographical area. In this study, environmental and clinical isolates of NTM and their sensitivity to ethambutol has been determined.Methods: 41 clinical and environmental isolates from Isfahan, Iran, were identified by conventional phenotypic methods. To determine sensitivity to ethambutol, the isolates were tested in 2, 5, and 10 μg/ml antibiotic concentrations by agar microdilution method.Findings: The identified isolates included M. fortuitum (27 cases), M. gordonae (10 cases) M. smegmatis (1 case), M. abscessus (2 cases), and M. conceptionense (1 case). All of the clinical and environmental isolates were resistant to ethambutol except M. conceptionense which was susceptible in 5 and 10 μg/ml ethambutol concentrations [minimum inhibitory concentration (MIC): less than 5 μg/ml].Conclusion: Due to high frequency of ethambutol resistance in rapid- and slow-growing species of NTM, treatment strategy in this group of patients should be undertaken with caution and more effective drug should be considered.

Keywords

References

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Journal of Isfahan Medical School
Volume 31, Issue 234 - Serial Number 234
March and April 2013
Pages 558-564

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History

  • Receive Date: 10 March 2013
  • Revise Date: 27 May 2024
  • Accept Date: 06 April 2022

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