بررسی تأثیر مصرف مکمل اسید لینولئیک مزدوج بر ترکیب بدن

نوع مقاله : مقاله مروری

نویسندگان

1 کارشناس ارشد، گروه علوم بهداشتی در تغذیه، معاونت بهداشتی، دانشگاه علوم پزشکی زاهدان، زاهدان، ایران

2 دانشیار، مرکز تحقیقات امنیت غذایی، گروه تغذیه‌ی جامعه، دانشکده‌ی تغذیه و علوم غذایی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

چکیده

مقدمه: اسید لینولئیک مزدوج (CLA یا Conjugated linoleic acids) به گروهی از ایزومرهای اسید لینولئیک (18:2) که یک اسید چرب ضروری است، اطلاق می‌شود. به نظر می‌رسد اسید لینولئیک مزدوج یک مکمل رژیمی برای کاهش وزن و چربی بدن می‌باشد. مطالعه‌ی حاضر با هدف بررسی تأثیر مصرف این مکمل بر ترکیب بدن انجام شد.روش‌ها: ابتدا از پایگاه‌های Pubmed و SID مقالاتی که در عنوان خود دارای یکی از کلمات Conjugated linoleic acid، Body composition، Adipose tissue، Lean body mass، BMI، Obesity، Weight retention و Free fatty acid بودند، انتخاب شدند و در نهایت 22 مقاله مورد بررسی قرار گرفتند.یافته‌ها: مطالعات متعدد نشان دادند که مکمل اسید لینولئیک مزدوج سبب کاهش وزن و کاهش توده‌ی چربی در کوتاه مدت در انسان می‌شود و در مورد اثرات مصرف طولانی مدت مکمل اسید لینولئیک مزدوج بر ترکیب بدن، نتایج متفاوتی به دست آمده است. مطالعات انجام شده بر ترکیب بدن از نظر دوز مصرفی اسید لینولئیک مزدوج، طول مدت مطالعه، افراد شرکت کننده در مطالعه، فعالیت فیزیکی، نمایه‌ی توده‌ی بدنی (طبیعی، اضافه وزن و درجه‌های متفاوت چاقی)، گروه سنی، تعداد افراد شرکت کننده، پذیرش کپسول‌ها و نوع ایزومرهای اسید لینولئیک مزدوج متنوع بودند. به نظر می‌رسد ایزومر 10t،12c از بین ایزومرهای مختلف اسید لینولئیک مزدوج سبب تغییرات بهتری در ترکیب بدن می‌شود.نتیجه‌گیری: نتایج حاصل از مطالعات بالینی در مورد اثرات اسید لینولئیک مزدوج بر روی وزن و ترکیب بدن انسان متناقض است. پیشنهاد می‌گردد مطالعات طولانی مدت برای دیدن اثرات مصرف مکمل اسید لینولئیک مزدوج بر ترکیب بدن انجام شود. 

کلیدواژه‌ها

عنوان مقاله [English]

The Effect of Supplementation with Conjugated Linoleic Acid on Body Composition

نویسندگان [English]

  • Mahdiye Sheykhi 1
  • Leila Azadbakht 2
1 Department of Public Health in Nutrition, Health Deputy, Zahedan University of Medical Sciences, Zahedan, Iran
2 Associate Professor, Food Security Research Center AND Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده [English]

Background: Conjugated linoleic acid (CLA) is defined as isomers of linoleic acid group (18:2), which is an essential fatty acid. It seems that conjugated linoleic acid supplementation reduces body weight and fat mass. The aim of the present study was to investigate the effect of supplementation with conjugated linoleic acid on body composition.Methods: We used PubMed and SID search engine to find articles which were contained the following keywords: Conjugated linoleic acid, Body composition, Adipose tissue, Lean Body mass, BMI, Obesity, Weight retention, and Free fatty acid. After the search, 22 articles were recruited and reviewed.Findings: Several studies showed that supplementation of conjugated linoleic acid reduced body weight and fat mass in the short term in humans and long-term effects of this supplementation on body composition were inconsistent. Previous studies were diverted on body composition, dosage of conjugated linoleic acid, the period of the study, participants, physical activity, body mass index (normal, overweight and obesity in different degrees), age group, number of participants, capsule acceptance, and type of the conjugated linoleic acid isomers. It seemed that c12, t10 isomer caused a better change in body composition.Conclusion: The results of clinical studies on the effects of conjugated linoleic acid on weight and body composition are inconsistent. For see better effect of supplementation with conjugated linoleic acid on body composition, long-term studies are needed.

کلیدواژه‌ها [English]

  • Conjugated linoleic acid
  • Body composition
  • Lean body mass
  • Adipose tissue

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مجله دانشکده پزشکی اصفهان
دوره 32، شماره 305 - شماره پیاپی 305
آذر و دی 1393
صفحه 1728-1738

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  • تاریخ دریافت: 20 اسفند 1392
  • تاریخ بازنگری: 24 اردیبهشت 1403
  • تاریخ پذیرش: 17 فروردین 1401

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