The Effect of Pomegranate Juice Supplementation on Muscle Damage, Oxidative Stress and Inflammation Induced by Exercise in Healthy Young Men

Document Type : Original Article(s)

Authors

1 MSc Student, Nutrition and Food Security Research Center AND Department of Nutrition, School of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

2 Professor, Department of Biostatistics and Epidemiology, School of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

3 Assistant Professor, Department of Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

4 Assistant Professor, Department of Motor Behavior, School of Physical Education and Sports Science, Alzahra University, Tehran, Iran

5 PhD Candidate, Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran

6 Assistant Professor, Nutrition and Food Security Research Center AND Department of Nutrition, School of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Abstract

Background: Epidemiological evidence has shown that antioxidant supplements may play an important role in preventing exercise-induced muscle damage and oxidative stress. Recent years, some researchers have shown high levels of unique compounds in pomegranate polyphenol antioxidants. The aim of this study was to evaluate the impact of natural pomegranate juice on oxidative stress, muscle damage and inflammation induced by exercise in healthy young men.Methods: This clinical trial study was conducted on 30 healthy young men who exercised 3 times a week and were eligible for the study. They was randomly divided into two experimental (supplement) and control (placebo) groups. Experimental group received a daily cup of 250 ml of natural pomegranate juice, prepared by the researcher, and the control group received a daily cup of 250 ml of placebo, for 8 weeks at the same time. Blood samples were collected after at least 8 hours of fasting to assess indicators of muscle damage including creatine kinase (CK) and lactate dehydrogenase (LDH), lipid peroxidation including malondialdehyde (MDA) and inflammation including C-reactive protein (CRP), at the beginning and end of the study. Statistical analysis was performed using the paired and independent-samples t test.Findings: Following 8 weeks of consumption of pomegranate juice, MDA levels decreased from 1.5 to 1.1 μmol/l in pomegranate group and increased from 1.5 to 1.7 μmol/l in control group. The change of this indicator was significantly different between the two groups (P = 0.047). Changes in LDH, CRP and CK were not significant in any of the groups.Conclusion: The findings of this study suggest potential beneficial effects of pomegranate juice in strengthening the antioxidant defense system and reducing oxidative stress. 

Keywords

References

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Journal of Isfahan Medical School
Volume 32, Issue 320 - Serial Number 320
November and December 2015
Pages 2464-2472

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History

  • Receive Date: 19 March 2015
  • Revise Date: 10 May 2024
  • Accept Date: 06 April 2022

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