بازسازی سلول‌های شبکیه‌ی چشم توسط سلول بنیادی

نوع مقاله : Review Article

نویسندگان

1 کارشناس ارشد، مرکز تحقیقات بیماری‌های ارثی کودکان، پژوهشکده‌ی پیشگیری اولیه از بیماری‌های غیرواگیر و گروه ژنتیک و بیولوژی مولکولی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

2 استادیار، مرکز تحقیقات بیماری‌های ارثی کودکان، پژوهشکده‌ی پیشگیری اولیه از بیماری‌های غیرواگیر و گروه ژنتیک و بیولوژی مولکولی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

چکیده

در بیماری‌هایی چون دژنراسیون ماکولا وابسته به سن (AMD یا Age-related macular degeneration)، رتینیت پیگمنتوزا (RP یا Retinitis pigmentosa) و ... با از بین رفتن سلول‌های شبکیه، دید مرکزی شبکیه از بین می‌رود. تاکنون راهی به منظور جایگزینی کل چشم یافت نشده است، اما جایگزینی سلول‌های شبکیه موفقیت‌هایی را در جانوران داشته است، با این که این راه کار هنوز درمان قطعی را در انسان ایجاد نکرده است. به منظور جایگزینی سلول‌های شبکیه، سلول‌های بنیادی در مناطق مختلف چشم از قبیل اجسام مژکی، عنبیه، Müller glia، سلول‌های بنیادی مغز استخوان و نیز سلول‌های جنینی استفاده شده است. در این مقاله‌ی مروری، ما با تأکید بر وجود فاکتورهای رشد در القا و تمایز سلول‌های بنیادی به بازسازی نورون‌های ویژه‌ی شبکیه می‌پردازیم. 

کلیدواژه‌ها

عنوان مقاله [English]

Retinal Cell Regeneration by Stem Cells

نویسندگان [English]

  • Fatemeh Nazem-Roaya 1
  • Razieh Heidari 1
  • Majid Kheirollahi 2
1 Pediatric Inherited Diseases Research Center, Research Institute for Primordial Prevention of Non-communicable disease AND Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Assistant Professor, Pediatric Inherited Diseases Research Center, Research Institute for Primordial Prevention of Non-communicable disease AND Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده [English]

A number of different cellular sources of neural stem cells have been identified. These sources include stem cells at the retinal margin, pigmented cells in the ciliary body and iris, non-pigmented cells in the ciliary body and Müller glia within the retina and also embryo and adult neural stem cells (NSCs). In the present review, we discuss the combinations of growth factors that are capable of stimulating the proliferation and making of neurons from stem cells, neural progenitors, non-neural epithelial cells, and postmitotic support cells.

کلیدواژه‌ها [English]

  • Stem cell
  • Retina
  • Eye

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مجله دانشکده پزشکی اصفهان
دوره 33، شماره 321 - شماره پیاپی 321
فروردین و اردیبهشت 1394
صفحه 54-69

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سابقه مقاله

  • تاریخ دریافت: 06 تیر 1393
  • تاریخ بازنگری: 23 اردیبهشت 1403
  • تاریخ پذیرش: 17 فروردین 1401

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