Comparing the Efficacy of Synthetic Fibrinogen Plus Albumin to Fresh Frozen Plasma in the Prevention of Coagulation Disorders in Pediatric Heart Surgery

Document Type : Original Article (s)

Authors

1 Associate Professor, Department of Anesthesiology and Critical Care, School of Medicine AND Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Iran

2 Assistant Professor, Department of Cardiosurgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 Student of Medicine, School of Medicine AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran

4 Department of Anesthesiology, Chamran Hospital, Isfahan, Iran

5 Department of Nursing, Chamran Hospital, Isfahan, Iran

6 Assistant Professor, Department of Anesthesiology and Critical Care, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Abstract

Background: Hemorrhage after cardiopulmonary bypass is one of the most important complications of pediatric heart surgery and fresh frozen plasma (FFP) infusion is the first intervention to compensate for the lost blood. Some studies show that injecting  combined fibrinogen and albumin can also compensate for this lost blood.  Thus, the aim of this study was to compare the effect of synthetic fibrinogen plus albumin with fresh frozen plasma for the prevention of coagulation disorders in pediatric heart surgery.Methods: In this clinical-trial study 90 candidates for pediatric heart surgery were selected and randomly divided in two groups. The first group received fresh frozen plasma and the second group received combined fibrinogen and albumin. Serum hemoglobin, serum platelets count, serum fibrinogen level, prothrombin time, partial thromboplastin time, activated clotting time, arterial blood gas were measured before and after the surgery and compared between the two groups.Findings: Before undergoing the surgery, mean serum level of hemoglobin in FFP and fibrinogen/albumin groups was 10.6 ± 1.9 and 11.9 ± 3.3, respectively and no statistical difference between the two groups were reported (P = 0.29). one hour after surgery this number was 12.9 ± 2.2 and 12.3 ± 2.3 in the two groups respectively (p = 0.18) and 24 hour after surgery  it was reported as 12.9 ± 1.7 and 13.1 ± 2.6 respectively which was not statistically different between the two groups (P = 0.69). Also, no statistical difference was reported between the two groups in changes of mean hemoglobin level before and after the study (P = 0.75).Conclusion: According to the results of this research, using a combination of fibrinogen and albumin had the same effect for prevention of post-surgical coagulation disorders and is suitable for children undergoing pediatric heart surgery if there are not any other contraindications for their use.

Keywords

References

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Journal of Isfahan Medical School
Volume 34, Issue 369 - Serial Number 369
January and February 2016
Pages 11-19

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History

  • Receive Date: 19 October 2015
  • Revise Date: 23 May 2024
  • Accept Date: 06 April 2022

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