Evaluation of the Effectiveness of Topical Zinc Acetate 1.2% for Pruritus and Erythema of Seborrheic Dermatitis in Patients under Treatment with Ketoconazole 2% Solution

Document Type : Original Article (s)

Authors

1 Assistant Professor, Skin Diseases and Leishmaniasis Research Center AND Department of Dermatology, School of Medicine, Isfahan University of Medical sciences, Isfahan, Iran

2 Professor, Skin Diseases and Leishmaniasis Research Center AND Department of Dermatology, School of Medicine, Isfahan University of Medical sciences, Isfahan, Iran

3 Student of Medicine, School of Medicine AND Student Research Committee, Isfahan university of Medical Sciences, Isfahan, Iran

4 Professor, Skin Diseases and Leishmaniasis Research Center, Department of Biostatics and Epidemiology, Isfahan University of Medical sciences, Isfahan, Iran

5 Associate Professor, Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran

Abstract

Background: Seborrheic dermatitis is chronic disease and in some cases despite an appropriate treatment, symptoms continue, therefore the aim of this study was evaluation of the effectiveness of topical zinc acetate in treatment of seborrheic dermatitis.Methods: This was a single blinded randomized clinical trial and study population consisted of 60 patients with seborrheic dermatitis in face or skull referring to dermatology clinics affiliated to Isfahan University of Medical Sciences, Isfahan, Iran. Patients were divided to two groups; first groups received Ketoconazole 2% solution and a placebo solution while the second group received both ketoconazole 2% solution and zinc acetate 1.2% solution. After collecting data, SPSS software was used for data analysis via t test and chi-square.Findings: The results of this study shows this medication significantly improved pruritus but was ineffective for erythema. Before this test, pruritus  in case group was 2.63±  2.41 and in control group was 2.57 ± 2.35 and after treatment pruritus in case group was 1.05 ± 0.70 and in control group was 1.59 ± 1.07, which according to the test, significant difference was observed between groups using chi-square test (P < 0.05). Before test, erythema in case group was 1.23±  0.43 and in control group was 1.07 ± 0.58 and after treatment in case group was 0.63 ± 0.66 and in control group was 0.66  ±0.62, there was no significant difference between the two groups (P > 0.05).Conclusion: The results of this study encourage using zinc acetate1.2% in the treatment of seborrheic dermatitis so we can improve the quality of life of patients by decreasing pruritus and also this study suggests to measure other effects of zinc acetate on other symptoms such as Scaling.

Keywords

References

  1. Gary G. Optimizing treatment approaches in seborrheic dermatitis. J Clin Aesthet Dermatol 2013; 6(2): 44-9.
  2. Bolognia JL, Jorizzo JL, Rapini RP. Dermatology. 2nd ed. Philadelphia, PA: Elsevier; 2008. p. 197-200.
  3. Holden CA, Berth-Jones J. Eczema, lichenification, prurigo and erythroderma. In: Burns T, Breathnach S, Cox N, Griffiths C, editors. Rook's textbook of dermatology. 7th ed. Hoboken, NJ: Willey; 2004. p. 699-754.
  4. Ozturk P, Arican O, Belge KE, Karakas T, Kabakci B. Oxidative stress in patients with scalp seborrheic dermatitis. Acta Dermatovenerol Croat 2013; 21(2): 80-5.
  5. Reygagne P, Poncet M, Sidou F, Soto P. Clobetasol propionate shampoo 0.05% in the treatment of seborrheic dermatitis of the scalp: results of a pilot study. Cutis 2007; 79(5): 397-403.
  6. Joshi VV. Stress: From burnout to balance. 1st ed. London, UK: SAGE Publications; 2005.
  7. Attarzadeh Y, Asilian A, Shahmoradi Z, Adibi N. Comparing the efficacy of Emu oil with clotrimazole and hydrocortisone in the treatment of seborrheic dermatitis: A clinical trial. J Res Med Sci 2013; 18(6): 477-81.
  8. Shin H, Kwon OS, Won CH, Kim BJ, Lee YW, Choe YB, et al. Clinical efficacies of topical agents for the treatment of seborrheic dermatitis of the scalp: a comparative study. J Dermatol 2009; 36(3): 131-7.
  9. Guillard O, Fauconneau B, Piriou A, Pineau A. In vitro study of the antiseborrheic activity of zinc L-cysteate, a novel zinc compound, on rat preputial gland. Pharmacology 1997; 55(1): 54-8.
  10. Bolognia JL, Jorizzo JL, Schaffer JV. Dermatology. 3rd ed. Philadelphia, PA: Saunders; 2012.
  11. Hoseni MN. Comparison of oral and topical ketoconazole in patients with seborrheic dermatitis resistant [Thesis]. Shiraz, Iran: Shiraz University of Medical Sciences; 2000. p. 77. [In Persian].
  12. Herizchi H, Babaie Nejad S, Saniee S. Comparing the Efficacy of topical terbinafine 1% cream with topical ketoconazole 2% cream and placebo in the treatment of facial seborrhoeic dermatitis. Med J Tabriz Univ Med Sci 2012; 34(1): 103-8. [In Persian].
  13. Bagherikia F, Behzadpour MA, Gharebaglo M, Chavoshi ZS. Comparison of two methods seborrhea dermatitis to topically and locally-food. 8th Annual Congress of Eastern Medical Sciences Student; 2012 Nov 14-15; Bojnord, Iran.
Journal of Isfahan Medical School
Volume 34, Issue 378 - Serial Number 378
March and April 2016
Pages 362-366

Files

History

  • Receive Date: 21 December 2015
  • Revise Date: 26 May 2024
  • Accept Date: 06 April 2022

Share

How to cite

Statistics