The Effect of Intravenous Tranexamic Acid on Perioperative Bleeding and Surgeon's Satisfaction during Mastoidectomy

Document Type : Original Article (s)

Authors

1 Associate Professor, Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

2 Student of Medicine, Students Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 Anesthesia Registered Nurse, Alzahra Hospital, Isfahan, Iran

Abstract

Background: To increase the quality of surgery, getting to low levels of perioperative bleeding is needed in mastoidectomy; however, the existing methods have some complications. The aim of this study was to evaluate the effect of intravenous tranexamic acid on bleeding volume and surgeon's satisfaction during mastoidectomy.Methods: In this randomized clinical trial study, 69 patients with indications of mastoidectomy were evaluated. After obtaining informed consent, the patients were divided into two groups randomly. The case group received infusion of remifentanil (0.1 μg/kg/minute) during surgery as well as tranexamic acid (10 mg/kg) at the beginning of surgery. The control group received only remifentanil (0.2 μg/kg/minute) during the surgery. The mean volume of bleeding, hemodynamic parameters and the surgeon's satisfaction were compared between the groups.Findings: The mean bleeding volumes were 62.1 ± 16.6 and 89.0 ± 25.5 ml in the case and control groups, respectively (P < 0.001). The rate surgeon's “great satisfaction” was 82.4% and 40.0% in case and control groups, respectively (P = 0.004). The mean arterial pressure at 30 minutes after the surgery was lower in the cases than the controls (86.4 ± 5.5 vs. 90.4 ± 4.7 mmHg; P = 0.002).Conclusion: Our study showed that the administration of tranexamic acid is associated with lower perioperative bleeding and also increased surgeon's satisfaction. As the mean arterial pressure was lower in these patients, careful monitoring of the blood pressure is necessary during the surgery.

Keywords

References

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Journal of Isfahan Medical School
Volume 34, Issue 415 - Serial Number 415
November and December 2017
Pages 1653-1659

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History

  • Receive Date: 09 August 2016
  • Revise Date: 26 May 2024
  • Accept Date: 06 April 2022

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