One-Year Renal Function in Patients with Chronic Renal Failure and Metabolic Syndrome

Document Type : Original Article (s)

Authors

1 Professor, Kidney Diseases Research Center AND Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Student of Medicine, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 Associate Professor, Kidney Diseases Research Center AND Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

4 Professor, Department of Biostatistics and Epidemiology, School of Health, Isfahan University and Medical Sciences, Isfahan, Iran

5 Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Recently, chronic renal failure (CRF) has increased worldwide. CRF is a major risk factor to end-stage renal diseases. The incidence of metabolic syndrome (MS) and its cardiovascular complications is common in patients CRF, too. In this study, we compared renal function in patients with CRF and with or without metabolic syndrome.Methods: This study was conducted in 2017 among 100 patient with CRF with glomerular filtration rate (GFR) of 15-60 ml/min/1.73m2, 50 patients with and 50 without metabolic syndrome. Metabolic syndrome criteria, as well as serum creatinine were measured in all the patients each 3 months till 1 year.Findings: 42 patients were women and 58 were men. The mean GFR was not significantly different among the patients with or without metabolic syndrome (P = 0.322) in 1-year follow up. In 3-month follow ups, only there was a significant association between systolic blood pressure and GFR with metabolic syndrome (P = 0.028, P = 0.030, P = 0.020, and P = 0.15 in 1st, 2nd, 3rd, and 4th 3-month follow up). In 1-year follow up, there was no significant association between other metabolic syndrome criteria and GFR in patients with metabolic syndrome [P = 0.214, P = 0.061, P = 0.409, P = 0.315, and P = 0.284 for abdominal obesity, diastolic blood pressure, triglyceride, high-density lipoprotein (HDL), and fasting blood sugar (FBS)].Conclusion: Metabolic syndrome does not any effect on renal function in patients with CRF. We recommend further studies with longer follow-up period.

Keywords

References

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Journal of Isfahan Medical School
Volume 36, Issue 496 - Serial Number 496
July and August 2018
Pages 1100-1105

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History

  • Receive Date: 02 September 2018
  • Revise Date: 27 May 2024
  • Accept Date: 06 April 2022

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