The Effect of Vitamin D Supplement on Outcomes in Patients with Traumatic Injuries Hospitalized in Intensive Care Unit: A Clinical Trial Study

Document Type : Original Article (s)

Authors

1 Associate Professor, Anesthesiology and Critical Care Research Center AND Nosocomial Infection Research Center AND Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Associate Professor, Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 Professor, Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

4 Resident, Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: As published in literature, vitamin D deficiency lead to increased morbidity and mortality rate in patients who hospitalized in intensive care units (ICUs). The present study conducted to evaluate the effect of vitamin D supplement on outcomes in patients with traumatic injuries hospitalized in ICU.Methods: In a clinical trial study, 55 patients with low levels of vitamin D (less than 30 ng/ml) and 55 patients with normal levels of vitamin D were selected from the patients admitted to the ICU of Alzahra hospital, Isfahan, Iran. The patients suffering hypovitaminosis D (interventional group) received 300,000 units of vitamin D intramuscularly. Patients who had adequate vitamin D levels were considered as control group. The patients’ recovery from the ICU was evaluated and compared by the Sequential Organ Failure Assessment (SOFA) index.Findings: SOFA scores were significantly higher in vitamin D deficiency group in first 2 weeks after hospitalization. Serum vitamin D levels at the end of the 3rd week had no statistical different between the two groups. The discharge rate in vitamin D deficiency group in first 2 weeks were lower than control group significantly. But at the end of the third week, the difference between the two groups was not significant.Conclusion: The results of our study showed that vitamin D supplement increased discharge rate of traumatic patients hospitalized in ICU.

Keywords

References

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Journal of Isfahan Medical School
Volume 38, Issue 590 - Serial Number 590
July and August 2020
Pages 649-654

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History

  • Receive Date: 24 July 2020
  • Revise Date: 26 May 2024
  • Accept Date: 06 April 2022

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