تأثیر تمرین ورزشی بر مارکرهای التهابی در بیماران مبتلا به استئوآرتریت و روماتوئید آرتریت: مروری نظام‌مند و فراتحلیل

نوع مقاله : مقاله مروری

نویسندگان

1 استادیار، گروه تربیت بدنی و علوم ورزشی، دانشکده‌ی علوم انسانی، دانشگاه کاشان، کاشان، ایران

2 دانشجوی کارشناسی ارشد، گروه تربیت بدنی و علوم ورزشی، دانشکده‌ی علوم انسانی، دانشگاه کاشان، کاشان، ایران

3 کارشناسی ارشد، گروه فیزیولوژی ورزشی، دانشکده‌ی علوم ورزشی، دانشگاه گیلان، گیلان، ایران

4 دانشیار، گروه تربیت بدنی و علوم ورزشی، دانشکده‌ی علوم انسانی، دانشگاه کاشان، کاشان، ایران

چکیده

مقاله مروری




مقدمه: استئوآرتریت (Osteoarthritis) OA و روماتوئید آرتریت (Rheumatoid arthritis) RA با گسترش التهاب مزمن، افزایش سایتوکین‌های پیش‌التهابی و کاهش سایتوکین‌های ضدالتهابی همراه است. درحالی ‌که اثرات تمرین ورزشی بر مارکرهای التهابی در این بیماران بیان نشده است. هدف از مطالعه‌ی حاضر، بررسی اثر تمرینات ورزشی بر مارکرهای التهابی در بیماران مبتلا به OA و RA می‌باشد.
روش‌ها: جستجوی نظام‌مند در پایگاه‌های اطلاعاتی PubMed، Web of Science، Scopus، Google Scholar برای مقالات انگلیسی و فارسی منتشر شده تا
10 اسفند 1401 انجام شد. فراتحلیل برای مطالعات تمرین ورزشی در برابر گروه کنترل بر روی مارکرهای التهابی IL-6، TNF-α و CRP صورت گرفت. برای تعیین اندازه‌ی اثر از تفاوت میانگین استاندارد شده (SMD) و فاصله‌ی اطمینان 95 درصد (CIs) با استفاده از نرم‌افزار CMA3 استفاده شد.
یافته‌ها: 15 مطالعه‌ شامل 660 آزمودنی مبتلا به OA و RA وارد فراتحلیل شدند. نتایج نشان داد که تمرین ورزشی منجر به کاهش معنی‌دار TNF-α [0/02 = P،
(0/15- الی 1/76CI: -) 43/0-] و CRP [0/001 = P، (0/35- الی 1/47CI: -) 0/91-] شد، درحالی ‌که اثر تمرین ورزشی بر کاهش IL-6 [0/12 = P، (0/100 الی 0/91CI: -) 40/0-] معنی‌دار نبود.
نتیجه‌گیری: تمرین ورزشی ممکن است منجر به کاهش مارکرهای التهابی در بیماران مبتلا به OA و RA می‌شود. بهبود التهاب با تمرین ورزشی ممکن است دلیلی برای اثر مفید تمرین ورزشی در این بیماران باشد.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The Effect of Exercise Training on Inflammatory Markers in Patients with Osteoarthritis and Rheumatoid Arthritis: A Systematic Review and Meta-Analysis

نویسندگان [English]

  • Mousa Khalafi 1
  • Piunik Hovsepian 2
  • Mohammad Hossein Sakhaei 3
  • Keyvan Sharifmoradi 4
1 Assistant Professor, Department of Physical Education and Sport Sciences, School of Humanities, University of Kashan, Kashan, Iran
2 MSc Student, Department of Physical Education and Sport Sciences, Faculty of Humanities, University of Kashan, Kashan, Iran
3 MSc, Department of Exercise Physiology, School of Sport Sciences, University of Guilan, Guilan, Iran
4 Associate Professor, Department of Physical Education and Sport Sciences, School of Humanities, University of Kashan, Kashan, Iran
چکیده [English]

Background: Osteoarthritis (OA) and rheumatoid arthritis (RA) are associated with the development of chronic inflammation, increase of pro-inflammatory cytokine, and decrease of anti-inflammatory cytokine. However, the effects of exercise training on inflammatory markers in these patients are not understood. This study aims to investigate the effect of exercise on inflammatory markers in patients with OA and RA.
Methods: A systematic search was conducted in PubMed, Scopus, Web of Science, and Google Scholar databases for English and Persian-published articles until March 1, 2024. Meta-analysis was conducted for the studies of exercise training against the control group on the inflammatory markers including IL-6, TNF-α and CRP. To determine the effect size, standardized mean difference (SMD) and 95% confidence interval (CIs) were used using CMA3 software.
Findings: 15 studies involving 660 subjects with OA and RA were included in the meta-analysis. The results showed that exercise training resulted in a significant decrease in TNF-α [-0.43 (CI: -1.76 to -0.15), P = 0.02] and CRP [-0.91, (CI: -1.47 to -0.35 CI), P = 0.001], while the effect of exercise training on the reduction of IL-6 [-0.40 (CI: -0.91 to 0.10), P = 0.12] was not significant.
Conclusion: Exercise training may lead to the reduction of inflammatory markers in patients with OA and RA. Improvement of inflammation with exercise training may be the reason for the beneficial effect of exercise training in these patients.

کلیدواژه‌ها [English]

  • Exercise Training
  • Cytokines
  • Inflammation
  • CRP
  • Osteoarthritis
  • Rheumatoid Arthritis

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مجله دانشکده پزشکی اصفهان
دوره 41، شماره 725
هفته 1، شهریور
مرداد و شهریور 1402
صفحه 524-535

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  • تاریخ دریافت: 07 اردیبهشت 1402
  • تاریخ بازنگری: 10 خرداد 1402
  • تاریخ پذیرش: 10 خرداد 1402

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