The Effect of Ferula Asaferida Aqueous Extract on Enzymatic Changes and Liver Damage Caused by Thioacetamide Toxicity

Document Type : Original Article (s)

Authors

1 DVM Student, Veterinary Medicine, Department of Pharmacology, Karaj Branch, Islamic Azad University, Karaj, Iran

2 Assistant Professor, Department of Pharmacology, Karaj Branch, Islamic Azad University, Karaj, Iran

3 Assistant Professor, Department of Clinical Sciences, Karaj Branch, Islamic Azad University, Karaj, Iran

Abstract

Background: Ferula asaferida (FA), a medicinal plant with antioxidant and anti-inflammatory properties- has beneficial effects on various diseases. Herein, we investigated the impact of the FA aqueous extract on enzyme activity and liver damage caused by thioacetamide (Th) toxicity.
Methods: 48 Wistar rats were randomly divided into six groups: 1. control, 2. Th, 3. thioacetamide and plant extract (ThPE50) (50 mg/kg of PE), 4. ThPE100 (100 mg/kg of PE), 5. ThPE200 (200 mg/kg of PE), and 6. PE. After 14 days of treatment, liver enzymes (ALT, ALP, AST) activity, oxidative stress indicators (SOD, MDA, GPX), and histological damages in the liver were examined in all animals.
Findings: The Th group had a significant difference from the control group in levels of ALT, ALP, AST SOD, MDA, and GPX, but the PE group did not have a significant difference from the control group. While in the ThPE groups, these values also showed a significant change due to increasing the dosage of PE (P < 0.0001). The histological examination showed that the control and the PE groups did not differ significantly from each other, but in the ThPE groups increment of the PE dosage can reduce the toxic effect of thioacetamide on hepatocytes leading to the decrement of tissue damage in liver (the most effect of PE was observed in 200 mg/kg dosage).
Conclusion: The use of Ferula asaferida extract in a dose-dependent manner causes a significant reduction in the toxicity of the thioacetamide, affecting the function and structure of liver cells.

Highlights

Zohreh Abdolmaleki: PubMed, Google Scholar

Seyedeh Parastoo Yasini: Google Scholar

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Journal of Isfahan Medical School
Volume 42, Issue 789
1st Week, January
January and February 2025
Pages 941-951

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History

  • Receive Date: 07 September 2024
  • Accept Date: 27 November 2024

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