The Effectiveness of Phytosomal Curcumin on Inflammation in Patients with Multiple Trauma Admitted to the Intensive Care Unit: A Double-Blind Randomized Placebo-Controlled Trial

Document Type : Original Article (s)

Authors

1 Professor, Anesthesia and Critical Care Research Center, Department of Anesthesia, Isfahan University of Medical Sciences, Isfahan, Iran

2 Anesthesia and Critical Care Research Center, Department of Anesthesia, Isfahan University of Medical Sciences, Isfahan, Iran

3 Association Professor, Anesthesia and Critical Care Research Center, Department of Anesthesia, Isfahan University of Medical Sciences, Isfahan, Iran

4 Assistant Professor, Nutrition and Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background:  Multiple trauma has serious complications, which increases the risk of morbidity and mortality in the patients. This study aimed to evaluate the impact of supplementation with phytosomal curcumin on CRP in critically ill patients with multiple traumas.
Methods: In this double-blind trial, 53 patients with multiple trauma who were admitted to the intensive care unit (ICU) were randomized to receive either two capsules, each capsule containing 250 mg phytosomal (a total of 500 mg daily) as an intervention group or two identical capsules (placebo capsules), each containing 250 mg maltodextrin for 7 days. Clinical and laboratory parameters were assessed before and after the intervention.
Findings: After seven days of intervention, quantitative C-reactive protein (CRP) (P = 0.044) levels significantly decreased in the curcumin compared with the placebo group.
Conclusion: Phytosomal curcumin had a beneficial effect on laboratory factor (CRP) in ICU-admitted patients with multiple trauma.

Highlights

Saeed Abbasi: Google Scholar, PubMed

Babak Alikiaii: Google Scholar, PubMed

Mohammad Bagherniya: Google Scholar, PubMed

Keywords

Main Subjects

References

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Journal of Isfahan Medical School
Volume 42, Issue 794
2nd Week, February
January and February 2025
Pages 1086-1094

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History

  • Receive Date: 23 June 2024
  • Accept Date: 06 October 2024

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