بهبود اثرات آنتی‌بیوتیک‌ها از طریق ریزپوشانی آن‌ها با نانوذرات

نوع مقاله : مقاله مروری

نویسندگان

1 دانشجوی دکترا، گروه میکروبیولوژی، واحد فلاورجان، دانشگاه آزاد اسلامی، اصفهان، ایران

2 استادیار، گروه میکروبیولوژی، واحد فلاورجان، دانشگاه آزاد اسلامی، اصفهان، ایران

چکیده

مقاله مروری




مقدمه: مقاومت باکتری‌های بیماری‌زا به عوامل ضد میکروبی به‌عنوان یک همه‌گیری خاموش محسوب می‌شود که اثربخشی آنتی‌بیوتیک‌ها و سایر داروهای ضد میکروبی را تهدید می‌کند.
روش‌ها: این مقاله از نوع مروری است و برای تهیه‌ی آن، مقالات اصیل از سال 2011 تا 2024 به‌صورت سیستماتیک با استفاده از پایگاه‌های Scopus، PubMed، Web of Science، BIO ONE و Google Scholar جستجو شدند. برای این منظور از کلمات کلیدی مرتبط شامل"Resistance to Antibiotics" ، "Encapsulation of Antibiotics in Nanoparticles"  و "Nanoparticles Safety" استفاده شد.
یافته‌ها: اندازه‌گیری تأثیر اجتماعی، اقتصادی و اثرهای زیست‌محیطی میکروارگانیسم‌های مقاوم به دارو دشوار است، اما قطعاً قابل توجه است. نانوداروهای مختلفی مبتنی بر نانوسیستم‌های آلی (مانند لیپوزوم‌ها، میسل‌های پلیمری و نانوذرات پلیمری) و نانوسیستم‌های معدنی برای مبارزه با پاتوژن‌های مقاوم به دارو مطرح شده‌اند. نانوذرات می‌توانند با تشکیل رادیکال‌های هیدروکسیل فعال، تغییرات در عملکردهای دفاعی سلولی و اثر ضدبیوفیلم، تأثیر هم‌افزایی بر آنتی‌بیوتیک‌ها داشته باشند. همچنین، نانوذراتی با سمیت کم، کارآیی بالا، توانایی نفوذ به داخل سلول‌های میزبان و قابلیت رهایش دارو در محل خاص، می‌توانند حامل‌های بسیار مؤثری برای آنتی‌بیوتیک‌ها باشند. از جمله این حامل‌ها، لیپوزوم‌ها با ویژگی‌های آب‌دوست و آب‌گریز، میسل‌های حامل داروهای محلول در آب و نانوذرات پلیمری هستند که مقاومت سویه‌های مقاوم به چند دارو و مقاومت بیوفیلم‌ها را می‌شکنند. در این میان، پلیمرهای زیست‌تخریب‌پذیر به‌دلیل ایمنی بالاتر، گزینه‌های مطلوب‌تری به شمار می‌آیند.
نتیجه‌گیری: سیستم‌های تحویل آنتی‌بیوتیک مختلفی با استفاده از نانوذرات ساخته شده‌اند، اما هنوز تحقیقات بیشتری برای طراحی سیستم‌های مؤثرتر با سطح ایمنی بالا لازم است.

تازه های تحقیق

Samereh Nouri: PubMed

Maryam Mohammadi Sichani: Google Scholar, PubMed

Nafiseh Sadat Naghavi: Google Scholar, PubMed

Gholam Reza Amiri: Google Scholar, PubMed

Laleh Hoveida: Google Scholar, PubMed

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Improving the Effects of Antibiotics Through Their Micro-Encapsulation with Nanoparticles

نویسندگان [English]

  • Samereh Nouri 1
  • Maryam Mohammadi Sichani 2
  • Nafiseh Sadat Naghavi 2
  • Gholam Reza Amiri 2
  • Laleh Hoveida 2
1 PhD Student, Department of Microbiology, Fal. C.,, Islamic Azad University, Isfahan, Iran
2 Assistant Professor, Department of Microbiology, Fal. C.,, Islamic Azad University, Isfahan, Iran
چکیده [English]

Background: Resistance of pathogenic bacteria to antimicrobial agents is a silent epidemic threatening the effectiveness of antibiotics and other antimicrobial drugs.
Methods: This article is a review and was prepared by systematically searching original articles from 2011 to 2024 using Scopus, PubMed, Web of Science, BIO ONE, and Google Scholar databases. For this purpose, related keywords, including "Resistance to antibiotics," "Encapsulation of antibiotics in nanoparticles," and "Nanoparticles safety" were used. After removing duplicate and unrelated studies, 59 studies were included.
Findings: Measuring the social, economic, and environmental impacts of drug-resistant microorganisms is challenging, but their significance is undeniable. Various nanomedicines based on organic nano-systems (liposomes, polymer micelles, and polymer nanoparticles) and inorganic nano-systems have been proposed to combat drug-resistant pathogens. Nanoparticles can have a synergistic effect on antibiotics by forming active hydroxyl radicals, changes in cellular defense activities, and anti-biofilm effects. Also, nanoparticles with low toxicity, high efficiency, the ability to penetrate the host cells, and the ability to release the drug at a specific location can be highly effective carriers for antibiotics. Among these carriers are liposomes with hydrophilic and hydrophobic properties, micelles carrying water-soluble drugs, and polymer nanoparticles that break the resistance of multidrug-resistant strains and biofilms. Meanwhile, biodegradable polymers have higher safety.
Conclusion: Various antibiotic delivery systems have been developed using nanoparticles, but further research is still needed to design more effective systems with a high level of safety.

کلیدواژه‌ها [English]

  • Antibacterial drug resistance
  • Nanoparticles
  • Antibiotic
  • Encapsulation

اصل مقاله

سامره نوری: PubMed

مریم محمدی سیچانی: Google Scholar, PubMed

نفیسه سادات نقوی: Google Scholar, PubMed

غلامرضا امیری: Google Scholar, PubMed

لاله هویدا: Google Scholar, PubMed

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مجله دانشکده پزشکی اصفهان
دوره 43، شماره 801
هفته 1، فروردین
فروردین و اردیبهشت 1404
صفحه 18-29

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  • تاریخ دریافت: 03 آبان 1403
  • تاریخ پذیرش: 16 دی 1403

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