Comparison of the Effect of Modified and Conventional Hemofiltration and the Combination of Both Methods During Coronary Artery Bypass Graft Surgery (CABG) on Kidney Function

Document Type : Original Article(s)

Authors

1 MSc Student in Circulatory Technology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Assistant Professor of Cardiovascular Surgery, Department of Surgery, Chamran Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

3 Associate Professor, Department of Epidemiology and Biostatics, Health School and Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

4 Certified Nurse, Cardiovascular Perfusionist, Chamran Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

5 MSc in Cardiovascular Perfusion, Cardiovascular Perfusionist, Chamran Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

6 Associate Professor of Cardiovascular Surgery, Department of Surgery, Chamran Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: While coronary artery surgery is a particular medical procedure, it can impact other organs, such as the kidneys. As such, this study seeks to compare the effects of hemofiltration, two new and prevalent methods, and a combination of the two methods during cardiopulmonary bypass surgery on kidney function.
Methods: This study was a clinical trial that involved 60 patients undergoing cardiopulmonary bypass in the open-heart surgery room of Chamran Hospital, Isfahan. The study utilized a three-arm and double-blind randomized approach with an easy and accessible sampling method. The three intervention methods tested were common ultrafiltration, modified ultrafiltration, and a combination. The data was analyzed with a significance level of 5%.
Findings: The serum creatinine mean (SD) of patients in the intervention group increased by 1.15 (± 0.20) within the initial 24 hours after surgery, compared to the mean value of 1.02 (± 0.10) before surgery. In the common method, the mean glomerular filtration rate (± standard deviation) decreased in the first 24 hours after surgery compared to its mean value before surgery, which was 66.74 (± 8.95).
Conclusion: Changing the method of ultrafiltration has no impact on kidney function. The reduction in 24-hour drainage volume was more effectively achieved through either a novel method alone or a combination of two methods compared to the conventional method alone.

Highlights

Mehran Shahzamani: PubMed

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References

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Haider A, Khwaja IA, Gull S, Nabi H, Khan I, Rehman HU. Zero balance versus conventional hemofiltration-impact on renal function and blood conservation in adult valvular cardiac surgery. Pakis J Med and Health Sci 2021; 15(9): 2314-8

Journal of Isfahan Medical School
Volume 43, Issue 804
4th Week, April
March and April 2025
Pages 87-94

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History

  • Receive Date: 20 April 2024
  • Accept Date: 17 February 2025

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