Paradoxical Effects of Adenovirus 36 in the Development of Obesity and Body Metabolic Conditions

Document Type : Letter to Editor

Authors

1 Professor, Nutrition and Metabolic Diseases Research Center, and Paramedical School, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

2 Assistant Professor, Department of Virology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

3 Professor, Endocrine and Metabolism Research Center of Isfahan. Isfahan University of Medical Sciences, Isfahan, Iran

4 Assistant Professor, Endocrine and Metabolism Research Center of Isfahan. Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Viral infections, especially adenovirus 36 (Ad-36) infection, are considered an important factor in the development of obesity. The effects of Ad-36 infection are contradictory. On the one hand, Ad-36 infection leads to weight gain and fat accumulation, increased inflammation, and entry of macrophages into fat cells, causing obesity. On the other hand, it leads to reduced insulin resistance, improved lipid profile, and glycemic control. These effects may partly explain the variability in individual responses to antidiabetic drugs such as metformin and pioglitazone. Moreover, Ad-36 infection may potentially influence the development of new antidiabetic drugs. Further studies in this field are necessary.

Highlights

Majid Karandish: Google Scholar, PubMed

Ali Teimoori: Google Scholar 

Mansour Siavash: Google Scholar 

Fatemeh Shirani: Google Scholar, PubMed

Keywords

Main Subjects

References

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Journal of Isfahan Medical School
Volume 43, Issue 805
1st Week, May
May and June 2025
Pages 112-114

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History

  • Receive Date: 24 July 2024
  • Accept Date: 17 February 2025

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