The Effect of Aerobic Training and Melatonin Consumption on Gene Expression of Some Inflammatory Factors and Antioxidant Index in Liver Tissue of Male Rats Diabetes

Document Type : Original Article (s)

Authors

1 Department of Physical Education & Sport Sciences, Sh.C., Islamic Azad University, Shoushtar, Iran

2 Department of Sport Sciences, MaS.C., Islamic Azad University, MasjedSoleiman, Iran

3 Department of Sport Sciences, School of Education and Psychology, Shiraz university, Shiraz, Iran

10.48305/jims.v43.i808.0244

Abstract

Background: Diabetes, as a systemic disease, can lead to tissue damage and decreased liver function by increasing reactive species. Therefore, the purpose of this research is to investigate the interactive effects of aerobic training and melatonin consumption on the gene expression of some inflammatory factors and antioxidant markers in the liver tissue of male Diabetic Rats.
Methods: In this experimental study, 30 eight-week-old Wistar rats were randomly selected and Diabetes was induced in 24 rats via a single injection of streptozotocin (55 mg/kg). Diabetic rats were divided into 4 groups including diabetes control (DC), diabetes melatonin (DMel), diabetes aerobic training (DEx), diabetes aerobic training+melatonin (DEx+Mel). A healthy control group (HC) was also considered. The aerobic training program consisted of 5 days a week, for 6 weeks. The data were analyzed using one-way analysis of variance and Tukey's post-hoc statistical tests in SPSS version 29 software, with significance set at P ≤ 0.05.
Findings: Aerobic training and melatonin intake resulted in a significant decrease in IL-18 (P = 0.001) and IL-1β
(P = 0.005) gene expression. On the other hand, it resulted in a significant increase in SOD, GPx, TAC values and a significant decrease in MDA values in the intervention groups (P = 0.001).
Conclusion: Results indicate enhanced antioxidant defense and reduced inflammatory factors. Based on the results of this study, it is suggested that aerobic training combined with melatonin intake is more beneficial than aerobic training and melatonin intake separately.

Highlights

Shirin Zilaei Bouri: PubMed , Google Scholar 

Farhad Daryanoosh: PubMed , Google Scholar

Keywords

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References

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Journal of Isfahan Medical School
Volume 43, Issue 808
4th Week, May
May and June 2025
Pages 244-254

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History

  • Receive Date: 09 November 2024
  • Accept Date: 05 May 2025

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