The Effect of High-Intensity Interval Training (HIIT) on the Content of Endoplasmic Reticulum (ER) Stress-Related Proteins in the Left Ventricle of the Heart of Type 2 Diabetic Rats

Document Type : Original Article (s)

Authors

1 Department of Sport Sciences, Apadana Institute of Higher Education, Shiraz, Iran

2 Department of Physical Education, Farhangian University, P.O. Box 14665-889, Tehran, Iran

3 Department of Sport Sciences, Apadana Institute of Higher Education, Shiraz, Iran.

10.48305/jims.v43.i808.0255

Abstract

Background: In recent years, high-intensity interval training (HIIT) has been considered as an effective exercise method to improve cardiovascular health in people with type 2 diabetes. Therefore, the aim of the current study is to the effect of HIIT on the content of proteins associated with the stress of endoplasmic reticulum such as PERK and NRF2 in the left ventricle of type 2 diabetic rats.
Methods: In this experimental study, 12 2-month-old male Sprague Dawley rats with an average weight of 280 ± 20 grams were selected. Type 2 diabetes was induced by injecting nicotinamide and streptozotocin solutions. The rats were randomly divided into 2 groups, resistance training and diabetic control; The HIIT program consisted of 5 bouts of 4 minutes with an intensity equal to 85 to 95% of the maximum speed (equivalent to 20 to 32 m/min) and active rest periods of 3 minutes with an intensity equal to 50 to 60% of the maximum speed (equivalent to 15 to 18 m/min). To analyze the data, one-way ANOVA and Tukey's post hoc tests. A significance level of P ≤ 0.05 is considered.
Findings: The HIIT program increases PPERK and NRF2 (P = 0.009 and P = 0.02, respectively) after 8 weeks of exercise in type 2 diabetic rats.
Conclusion: It seems that HIIT exercise can be recommended by health professionals for people with type 2 diabetes to prevent heart disease.

Highlights

Fatemeh Solhdoust: PubMed ,Google Scholar 

Hamed Alizadeh Pahlavani: PubMed ,Google Scholar

Mohammad Sherafati Moghadam: Google Scholar

Keywords

Main Subjects

References

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Journal of Isfahan Medical School
Volume 43, Issue 808
4th Week, May
May and June 2025
Pages 255-263

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History

  • Receive Date: 10 September 2024
  • Accept Date: 13 April 2025

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