Evaluation of Relative Frequency of Pathogens of Patients Admitted to PICU Ward and Their Antibiotic Resistance Pattern in Imam Hossein Pediatric Hospital in Isfahan

Document Type : Original Article(s)

Authors

1 Assistant Professor, Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

10.48305/jims.v43.i813.0438

Abstract

Background: Early diagnosis of disease-causing bacteria and predicting their response to antibiotics is one of the necessities of serving patients related to infectious diseases; Based on this, the study was conducted to determine the relative frequency of pathogens of patients admitted to the PICU ward and their antibiotic resistance patterns in Imam Hossein Pediatric Hospital in Isfahan.
Methods: This cross-sectional study was conducted between September 2018 and September 2019 at Imam Hossein (AS) Children's Hospital in Isfahan included children aged 1 to 21 years admitted to the hospital's PICU who had positive culture samples. Data were obtained from patient medical records. Frequency distribution and percentages were used to describe the data.
Findings: According to the findings of the study, the frequency of gram-negative bacteria was higher than gram-positive bacteria, and Staphylococcus epidermidis was the most common gram-positive bacteria with 14.66% and E. coli with 14.2% was the most common gram-negative bacteria.
Conclusion: Antibiotic resistance is a significant healthcare system problem associated with negative consequences in dealing with infectious diseases. The findings of this study are useful for treatment areas and hospitals that are related to such diseases.

Highlights

Behnoosh Mohammadi Jazi:  Google Scholar 

Keywords

Main Subjects

References

  1. Antibiotic resistance threats in the United States, Center for Disease Control and Prevention, U.S. Department of Health and Human Services: Washington DC, Published Online; 2013.
  2. Simpkin VL, Renwick MJ, Kelly R, Mossialos E. Incentivising innovation in antibiotic drug discovery and development: progress, challenges and next steps. J Antibiot (Tokyo) 2017; 70(12): 1087-96.
  3. World Health Organization. WHO Antimicrobial Resistance [accessed on 12 July 2019]. Geneva: Switzerland. World Health Organization; 2018.
  4. Simpkin VL, Renwick MJ, Kelly R, Mossialos E. Incentivising innovation in antibiotic drug discovery and development: progress, challenges and next steps. J Antibiot (Tokyo) 2017; 70(12): 1087-96.
  5. Abbas Q, Ul Haq A, Kumar R, Ali SA, Hussain K, Shakoor S. Evaluation of antibiotic use in Pediatric Intensive Care Unit of a developing country. Indian J Crit Care Med 2016; 20(5): 291-4.
  6. Punchak M, Hall K, Seni A, Buck WC, DeUgarte DA, Hartford E, et al. Epidemiology of disease and mortality from a PICU in mozambique. Pediatr Crit Care Med 2018; 19(11): e603–e610.
  7. Akova M. Epidemiology of antimicrobial resistance in bloodstream infections. Virulence 2016; 7(3): 252-66.
  8. Kumar A. Sagar H. A study on microbial profile and antibiotic resistance in pediatric intensive care unit in a tertiary care hospital. Indian Journal of Child Health. 2021; 8(2): 78-83.
  9. Li  S, Wei D. Analysis of antibiotic resistance of gram-negative bacteria in PICU. Chinese Pediatric Emergency Medicine 2018; 25(5): 372-6.
  10. El-Nawawy A, Ashraf GA, Antonios MAM, Meheissen MA, El-Alfy MMR. Incidence of Multidrug-Resistant Organism Among Children Admitted to Pediatric Intensive Care Unit in a Developing Country. Microb Drug Resist 2018; 24(8): 1198-206.
  11. Uc-Cachón AH, Gracida-Osorno C, Luna-Chi IG, Jiménez-Guillermo JG, Molina-Salinas GM. High prevalence of antimicrobial resistance among gram-negative isolated bacilli in intensive care units at a tertiary-care hospital in Yucatán Mexico. Medicina (Kaunas) 2019; 55(9): 588.
  12. Ulus A, Soner K. An evaluation of pediatric intensive care unit infection rates and various risk factors. Trends in Pediatrics, 2020; 1(2).
  13. Maldini B, Antolić S, Sakić-Zdravcević K, Karaman-Ilić M, Janković S. Evaluation of bacteremia in a pediatric intensive care unit: epidemiology, microbiology, sources sites and risk factors. Coll Antropol 2007; 31(4): 1083-8.
  14. Azimi T, Maham S, Fallah F, Azimi L, Gholinejad Z. Evaluating the antimicrobial resistance patterns among major bacterial pathogens isolated from clinical specimens taken from patients in Mofid Children's Hospital, Tehran, Iran: 2013-2018. Infect Drug Resist 2019; 12: 2089-102.
  15. Hamedi A, Amirian MH, Kouzegaran S. Nosocomial infections and antibiotic administration in pediatric department, imam reza hospital, Mashhad-Iran. J Ped Perspect 2014; 2(3): 157-61.
Journal of Isfahan Medical School
Volume 43, Issue 813
1st Week, July
July and August 2025
Pages 438-443

Files

History

  • Receive Date: 21 April 2025
  • Accept Date: 07 June 2025

Share

How to cite

Statistics