Comparative Study of the Preventive Effect of Two Different Doses of Intra-Cuff Dexamethasone on Sore Throat After Tracheal Tube Removal in Patients Undergoing Cesarean Section

Document Type : Original Article(s)

Authors

1 Professor, Department of Anesthesiology and Critical Care, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Associate Professor, Department of Anesthesiology and Critical Care, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 Medical Student, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

10.48305/jims.v43.i816.0536

Abstract

Background: Postoperative sore throat (POST) is a common complication following endotracheal intubation during general anesthesia, often impacting patient comfort and recovery. Dexamethasone, a glucocorticoid known for its anti-inflammatory properties, has been studied for its role in reducing POST, though the optimal dosage and route of administration remain under debate.
Methods: This prospective randomized triple-blind study compared the efficacy of intracuff dexamethasone at doses of 4 mg and 8 mg in reducing the incidence and severity of POST in women undergoing cesarean section. A total of 60 participants were randomly assigned to one of three groups: a control group receiving saline and two experimental groups receiving intracuff dexamethasone at 4 mg and 8 mg, respectively. The primary outcome measured was the severity of POST, assessed at 0, 6, 12, 18, and 24 hours postoperatively. Secondary outcomes included patient satisfaction and time to tolerate liquids and solids post-surgery.
Findings: According to the results, the mean severity of sore throat was significantly reduced in both the 8 mg and 4 mg dexamethasone groups (1.57 ± 1.15), (1.89 ± 1.47) (P < 0.05). Moreover, the 8 mg dexamethasone group demonstrated a significantly lower mean sore throat score compared with the control group (0.52 ± 0.24), (1.19 ± 0.88), (P < 0.01). Although the severity and intensity of sore throat were lower in the 8 mg group compared to the 4 mg group, this difference did not reach statistical significance (P = 0.78). Patient satisfaction was also higher in the 8 mg dexamethasone group compared with both the 4 mg and control groups (P < 0.01, P < 0.05).
Conclusion: Our findings suggest that while both dosages effectively reduce POST, higher doses may enhance patient comfort and satisfaction. Further studies are needed to explore the long-term implications of higher dexamethasone doses in various patient populations.

Highlights

Mitra Jabalameli: PubMed, Google Scholar

Behzad Nazemroaya: PubMed, Google Scholar  

Keywords

Main Subjects

References

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Journal of Isfahan Medical School
Volume 43, Issue 816
4th Week, July
July and August 2025
Pages 536-543

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History

  • Receive Date: 28 September 2024
  • Accept Date: 05 May 2025

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