The Effect of Different Doses of Labetalol on the Volume of Bleeding During and After Dacryocystorhinostomy Surgery

Document Type : Original Article(s)

Authors

1 Assistant Professor, Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Associate Professor, Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

4 Professor, Department of Anesthesiology, School of Medicine, Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

10.48305/jims.v43.i817.0590

Abstract

Background: The aim of this study was to determine the effect of different doses of labetalol on the volume of bleeding during dacryocystorhinostomy surgery.
Methods: In this clinical trial study, 90 patients who were candidates for dacryocystorhinostomy surgery were randomly divided into 3 groups (1 to 3) and immediately before the operation and if hemodynamics were stable, group 1 received labtalol 0.2 mg/kg, group 2 received labetalol 0.4 mg/kg and the control group received distilled water as a placebo with the same volume via intravenous infusion over 5 minutes. The volume of bleeding and hemodynamic variables were assessed. Data were analyzed using the chi-squared test.
Findings: The volume of bleeding during surgery and in recovery in the intervention groups was significantly lower than in the control group (P < 0.05). Additionally, there was no significant difference in intraoperative bleeding volume between the intervention groups during the study. Diastolic and systolic blood pressure and heart rate during the study in the intervention groups at 15 and 30 minutes after the start of surgery were significantly lower than in the control group, but there was no significant difference between the two intervention groups in this regard. Other measured parameters did not differ significantly between groups.
Conclusion: The use of labetalol in the intervention groups significantly reduced the volume of intraoperative bleeding during dacryocystorhinostomy, but no significant difference was observed between the 0.2 mg/kg and 0.4 mg/kg doses.

Highlights

Mohammad Montaseri: Google Scholar

Hamidreza Shetabi: Google Scholar

Darioush Moradi Farsani: Google Scholar

Keywords

Main Subjects

References

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Journal of Isfahan Medical School
Volume 43, Issue 817
1st Week, August
July and August 2025
Pages 590-597

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History

  • Receive Date: 05 April 2025
  • Accept Date: 09 June 2025

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